HUS1 Rabbit Polyclonal Antibody (CAB13938)
- SKU:
- CAB13938
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | HUS1 Rabbit Polyclonal Antibody |
SKU: | CAB13938 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human HUS1 (NP_004498.1). |
Sequence: | MKFR AKIV DGAC LNHF TRIS NMIA KLAK TCTL RISP DKLN FILC DKLA NGGV SMWC ELEQ ENFF NEFQ MEGV SAEN NEIY LELT SENL SRAL KTAQ NARA LKIK LTNK HFPC LTVS VELL SMSS SSRI VTHD IPIK VIPR KLWK DLQE PVVP DPDV SIYL PVLK TMKS VVEK MKNI SNHL VIEA NLDG ELNL KIET ELVC VTTH FKDL GNPP LASE STHE DRNV EHMA EVHI DIRK LLQF LAGQ QVNP TKAL CNIV NNKM VHFD LLHE DVSL QYFI PALS |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | hHUS1; HUS1 |
Positive Sample: | Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 32kDa |
Observed MW: | 32kDa |
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3364 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |