The HUNK Antibody (PAC020743) is a high-quality polyclonal antibody designed for research involving HUNK, a protein kinase that plays a key role in cell signaling pathways. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the HUNK protein, this antibody enables researchers to detect and analyze HUNK expression in a variety of cell types, providing valuable insights for studies in oncology and signal transduction.HUNK, also known as Hormonally up-regulated Neu-associated Kinase, is a critical regulator of cell proliferation and survival, making it a potential target for cancer therapy.
Its involvement in promoting tumor growth and metastasis makes it a promising candidate for further investigation in cancer research. Understanding the role of HUNK in cancer development and progression could lead to the development of targeted therapies that disrupt its signaling pathways, offering new approaches for treating various types of cancer.
Antibody Name:
HUNK Antibody (PACO20743)
Antibody SKU:
PACO20743
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human HUNK
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20743(HUNK Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine kinase. The human HUNK gene localizes to chromosome 21q22 and encodes a protein with nucleocytoplasmic distribution and localizes to the centrosome. Overexpression of the HUNK protein associates with approximately 50% of breast carcinomas, and may provide diagnostic-prognostic value as a molecular marker.
Synonyms:
hormonally up-regulated Neu-associated kinase
UniProt Protein Function:
HUNK: a protein kinase of the CAMKL family. Is developmentally regulated in a tissue-specific fashion. May contribute to changes in the mammary gland that occur during pregnancy in response to ovarian hormones. The active enzyme is localized in the nucleocytoplasm and the centrosome.Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; HUNK subfamilyChromosomal Location of Human Ortholog: 21q22.1Cellular Component: cytoplasm; nucleusBiological Process: multicellular organismal development; signal transduction
