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Human YY1 Recombinant Protein (RPPB5173)

SKU:
RPPB5173
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P25490
€309
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Description

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Product Name:Human YY1 Recombinant Protein
Product Code:RPPB5173
Size:20µg
Species:Human
Target:YY1
Synonyms:YY1 transcription factor, YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, Transcriptional repressor protein YY1, Delta transcription factor, Yin and yang 1, INO80 complex subunit S, YY-1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The YY1 solution (0.25mg/1ml) contains PBS, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMASGDTL YIATDGSEMP AEIVELHEIE VETIPVETIE TTVVGEEEEE DDDDEDGGGG DHGGGGGHGH AGHHHHHHHH HHHPPMIALQ PLVTDDPTQV HHHQEVILVQ TREEVVGGDD SDGLRAEDGF EDQILIPVPA PAGGDDDYIE QTLVTVAAAG KSGGGGSSSS GGGRVKKGGG KKSGKKSYLS GGAGAAGGGG ADPGNKKWEQ KQVQIKTLEG EFSVTMWSSD EKKDIDHETV VEEQIIGENS PPDYSEYMTG KKLPPGGIPG IDLSDPKQLA EFARMKPRKI KEDDAPRTIA CPHKGCTKMF RDNSAMRKHL HTHGPRVHVC AECGKAFVES SKLKRHQLVH TGEKPFQCTF EGCGKRFSLD FNLRTHVRIH TGDRPYVCPF DGCNKKFAQS TNLKSHILTH AKAKNNQ

YY1Transcription Factor, also known as YY1, is a part of the GLI-Kruppel class ofzinc finger proteins. YY1 has a positive and negativeeffect on a various cellular and viral genes by binding to sites overlappingthe transcription start site. YY1 leads histone deacetylases and histoneacetyltransferases to a promoter in order to activate or repress the promoter.

YY1 Human Recombinant produced in E. coli is a single polypeptide chain containing 437 amino acids (1-414) and having a molecular mass of 47.1kDa.YY1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).
NCBI Summary:YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
UniProt Code:P25490
NCBI GenInfo Identifier:3915889
NCBI Gene ID:7528
NCBI Accession:P25490.2
UniProt Secondary Accession:P25490,Q14935,
UniProt Related Accession:P25490
Molecular Weight:44,713 Da
NCBI Full Name:Transcriptional repressor protein YY1
NCBI Synonym Full Names:YY1 transcription factor
NCBI Official Symbol:YY1��
NCBI Official Synonym Symbols:DELTA; NF-E1; UCRBP; INO80S; YIN-YANG-1��
NCBI Protein Information:transcriptional repressor protein YY1
UniProt Protein Name:Transcriptional repressor protein YY1
UniProt Synonym Protein Names:Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1
Protein Family:YY1-associated factor
UniProt Gene Name:YY1��
UniProt Entry Name:TYY1_HUMAN

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