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Human YWHAZ Recombinant Protein (RPPB2689)

SKU:
RPPB2689
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P63104
Research Area:
Enzymes
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Description

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Product Name:Human YWHAZ Recombinant Protein
Product Code:RPPB2689
Size:20µg
Species:Human
Target:YWHAZ
Synonyms:YWHAZ, KCIP-1, MGC111427, MGC126532, MGC138156, 14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, Tyr-3/Trp- 5 Monooxygenase Activation Protein Zeta, 14-3-3 Zeta.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:YWHAZ solution containing 1xPBS pH-7.
Stability:YWHAZ Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMDK NELVQKAKLA EQAERYDDMA ACMKSVTEQG AELSNEERNL LSVAYKNVVG ARRSSWRVVS SIEQKTEGAE KKQQMAREYR EKIETELRDI CNDVLSLLEK FLIPNASQAE SKVFYLKMKG DYYRYLAEVA AGDDKKGIVD QSQQAYQEAF EISKKEMQPT HPIRLGLALN FSVFYYEILN SPEKACSLAK TAFDEAIAEL DTLSEESYKD STLIMQLLRD NLTLWTSDTQ GDEAEAGEGG EN

YWHAZ accession number NP_ 663723 belongs to the 14-3-3 family of proteins which are in charge for checkpoint control, apoptotic & nutrient sensing pathways as well as signal transduction by binding to phosphoserine-containing proteins. The 14-3-3 protein family is found in both plants and mammals, and KCIP-1 protein is 99% identical to the mouse, rat and sheep orthologs. KCIP-1 interacts with IRS1 protein, signifying a role in regulating insulin. 14-3-3 proteins are highly conserved and ubiquitously expressed. YWHAZ function as an adapter protein involved in the regulation of a large spectrum of both general and specialized signaling pathway. YWHAZ binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

YWHAZ fused to His Tag at N-terminus Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 245 amino acids (1-245) and having a molecular mass of 32kDa.YWHAZ is purified by proprietary chromatographic techniques.

UniProt Protein Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
NCBI Summary:This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
UniProt Code:P63104
NCBI GenInfo Identifier:52000887
NCBI Gene ID:7534
NCBI Accession:P63104.1
UniProt Secondary Accession:P63104,P29213, P29312, Q32P43, Q5XJ08, Q6GPI2, Q6IN74 Q6NUR9, Q6P3U9, Q86V33, A8K1N0, B7Z465,
UniProt Related Accession:P63104
Molecular Weight:19,333 Da
NCBI Full Name:14-3-3 protein zeta/delta
NCBI Synonym Full Names:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
NCBI Official Symbol:YWHAZ��
NCBI Official Synonym Symbols:HEL4; YWHAD; KCIP-1; HEL-S-3; HEL-S-93; 14-3-3-zeta��
NCBI Protein Information:14-3-3 protein zeta/delta
UniProt Protein Name:14-3-3 protein zeta/delta
UniProt Synonym Protein Names:Protein kinase C inhibitor protein 1; KCIP-1
Protein Family:14-3-3 protein
UniProt Gene Name:YWHAZ��

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