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Human YWHAQ Recombinant Protein (RPPB2688)

SKU:
RPPB2688
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P27348
Research Area:
Enzymes
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Description

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Product Name:Human YWHAQ Recombinant Protein
Product Code:RPPB2688
Size:20µg
Species:Human
Target:YWHAQ
Synonyms:14-3-3 theta, 14-3-3 tau, 14-3-3 T-cell, HS1, YWHAQ, 1C5, 14-3-3 Tau, Tyr-3/Trp- 5 Monooxygenase Activation Protein Theta.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:YWHAQ solution containing 20mM Tris 7.5.
Stability:YWHAQ Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWRVISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLKMKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYEILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA EGAEN

The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed.

YWHAQ Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 245 amino acids (1-245) and having a molecular mass of 27 kDa. YWHAQ is purified by proprietary chromatographic techniques.

UniProt Protein Function:14-3-3 theta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; focal adhesion; membrane; mitochondrion; protein complex

Molecular Function:protein binding; protein C-terminus binding; protein domain specific binding; protein N-terminus binding

Biological Process: apoptosis; gene expression; negative regulation of transcription, DNA-dependent; programmed cell death; small GTPase mediated signal transduction; substantia nigra development; transcription initiation from RNA polymerase II promoter

NCBI Summary:This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
UniProt Code:P27348
NCBI GenInfo Identifier:112690
NCBI Gene ID:10971
NCBI Accession:P27348.1
UniProt Secondary Accession:P27348,Q567U5, Q5TZU8, Q9UP48, D6W4Z5,
UniProt Related Accession:P27348
Molecular Weight:
NCBI Full Name:14-3-3 protein theta
NCBI Synonym Full Names:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
NCBI Official Symbol:YWHAQ��
NCBI Official Synonym Symbols:1C5; HS1; 14-3-3��
NCBI Protein Information:14-3-3 protein theta
UniProt Protein Name:14-3-3 protein theta
UniProt Synonym Protein Names:14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1
Protein Family:14-3-3 protein
UniProt Gene Name:YWHAQ��
UniProt Entry Name:1433T_HUMAN

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