Human VPS26A Recombinant Protein (RPPB5131)
- SKU:
- RPPB5131
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75436
Description
| Product Name: | Human VPS26A Recombinant Protein |
| Product Code: | RPPB5131 |
| Size: | 10µg |
| Species: | Human |
| Target: | VPS26A |
| Synonyms: | Vacuolar protein sorting-associated protein 26A, Vesicle protein sorting 26A, hVPS26, VPS26A, VPS26, HB58, PEP8A, Hbeta58. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | VPS26A protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.15M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSFLGGF FGPICEIDIV LNDGETRKMA EMKTEDGKVE KHYLFYDGES VSGKVNLAFK QPGKRLEHQG IRIEFVGQIE LFNDKSNTHE FVNLVKELAL PGELTQSRSY DFEFMQVEKP YESYIGANVR LRYFLKVTIV RRLTDLVKEY DLIVHQLATY PDVNNSIKME VGIEDCLHIE FEYNKSKYHL KDVIVGKIYF LLVRIKIQHM ELQLIKKEIT GIGPSTTTET ETIAKYEIMD GAPVKGESIP IRLFLAGYDP TPTMRDVNKK FSVRYFLNLV LVDEEDRRYF KQQEIILWRK APEKLRKQRT NFHQRFESPE SQASAEQPEM |
Vacuolar protein sorting-associated protein 26A (VPS26A) is a vital element of the retromer complex, which is required to recover lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Furthermore, VPS26A is essential in the regulation of transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Expression analysis in yeast and mammalian cells reveal that VPS26A interacts directly with VPS35 that functions as the core of the retromer complex.
VPS26A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 350 amino acids (1-327 a.a) and having a molecular mass of 40.6kDa.VPS26A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | VPS26A: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Belongs to the VPS26 family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 10q21.1 Cellular Component: cytosol; early endosome; endosome; endosome membrane; intracellular membrane-bound organelle; retromer complex; vesicle Molecular Function:protein binding; protein transporter activity Biological Process: intracellular protein transport; regulation of macroautophagy; retrograde transport, endosome to Golgi; Wnt receptor signaling pathway |
| NCBI Summary: | This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75436 |
| NCBI GenInfo Identifier: | 25453454 |
| NCBI Gene ID: | 9559 |
| NCBI Accession: | O75436.2 |
| UniProt Secondary Accession: | O75436,Q8TBH4, Q9H982, A8MZ56, B2RDD3, |
| UniProt Related Accession: | O75436 |
| Molecular Weight: | 28,938 Da |
| NCBI Full Name: | Vacuolar protein sorting-associated protein 26A |
| NCBI Synonym Full Names: | VPS26, retromer complex component A |
| NCBI Official Symbol: | VPS26A�� |
| NCBI Official Synonym Symbols: | HB58; PEP8A; VPS26; Hbeta58�� |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 26A |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 26A |
| UniProt Synonym Protein Names: | Vesicle protein sorting 26A; hVPS26 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS26A�� |
| UniProt Entry Name: | VP26A_HUMAN |
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