Human Vaspin Recombinant Protein (RPPB1061)
- SKU:
- RPPB1061
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8IW75
- Research Area:
- Cytokines
Description
| Product Name: | Human Vaspin Recombinant Protein |
| Product Code: | RPPB1061 |
| Size: | 25µg |
| Species: | Human |
| Target: | Vaspin |
| Synonyms: | Serpin A12 precursor, Visceral adipose-specific serpin, Visceral adipose tissue- derived serine protease inhibitor, Vaspin, OL-64, SERPINA12, Serine (or cysteine) proteinase inhibitor,clade A, antitrypsin, alpha-1 antiproteinase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | Vaspin in 20mM Tris pH-8, 0.2mM PMSF and 10% glycerol. |
| Stability: | Liquid Vaspin although stable at 10°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MLKPSFSPRN YKALSEVQGW KQRMAAKELA RQNMDLGFKL LKKLAFYNPG RNIFLSPLSI STAFSMLCLG AQDSTLDEIK QGFNFRKMPE KDLHEGFHYI IHELTQKTQD LKLSIGNTLF IDQRLQPQRK FLEDAKNFYS AETILTNFQN LEMAQKQIND FISQKTHGKI NNLIENIDPG TVMLLANYIF FRARWKHEFD PNVTKEEDFF LEKNSSVKVP MMFRSGIYQV GYDDKLSCTI LEIPYQKNIT AIFILPDEGK LKHLEKGLQV DTFSRWKTLL SRRVVDVSVP RLHMTGTFDL KKTLSYIGVS KIFEEHGDLT KIAPHRSLKV GEAVHKAELK MDERGTEGAA GTGAQTLPME TPLVVKIDKP YLLLIYSEKI PSVLFLGKIV NPIGK |
Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, which is a member of serine protease inhibitor family. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism.
Vaspin Human Recombinant produced in E.Coli is a single, non-glycosylated, His Tag, polypeptide chain containing 415 amino acids and having a molecular mass of 47 kDa.The Vaspin is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERPINA12: May modulate insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Inhibitor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 14q32.13 Cellular Component: extracellular space; plasma membrane Molecular Function:serine-type endopeptidase inhibitor activity Biological Process: positive regulation of phosphoinositide 3-kinase cascade; negative regulation of lipid biosynthetic process; negative regulation of gluconeogenesis; positive regulation of insulin receptor signaling pathway |
| UniProt Code: | Q8IW75 |
| NCBI GenInfo Identifier: | 74728144 |
| NCBI Gene ID: | 145264 |
| NCBI Accession: | Q8IW75.1 |
| UniProt Related Accession: | Q8IW75 |
| Molecular Weight: | 47,175 Da |
| NCBI Full Name: | Serpin A12 |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 |
| NCBI Official Symbol: | SERPINA12�� |
| NCBI Official Synonym Symbols: | OL-64�� |
| NCBI Protein Information: | serpin A12; vaspin; visceral adipose-specific SERPIN; visceral adipose tissue-derived serine protease inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 |
| UniProt Protein Name: | Serpin A12 |
| UniProt Synonym Protein Names: | OL-64; Visceral adipose tissue-derived serine protease inhibitor; Vaspin; Visceral adipose-specific serpin |
| Protein Family: | Serpin |
| UniProt Gene Name: | SERPINA12�� |
| UniProt Entry Name: | SPA12_HUMAN |
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