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Human Uteroglobin/SCGB1A1 Recombinant Protein (His Tag) (RPES5976)

SKU:
RPES5976
Product Type:
Recombinant Protein
Species:
Human
€289

Description

Product Name:Human Uteroglobin/SCGB1A1 Recombinant Protein (His Tag)
Product Code:RPES5976
Size:20µg
Species:Human
Expression Host:HEK293 Cells
Synonyms:Uteroglobin, Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, Secretoglobin family 1A member 1, Urinary protein 1, UP-1, UP1, Urine protein 1, SCGB1A1, CCSP, UGB
Mol Mass:9.9 kDa
AP Mol Mass:10 kDa
Tag:C-His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:Please contact us for more information.
Bio Activity:Testing in progress
Sequence:Glu22-Asn91
Accession:P11684
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:Uteroglobin is a small; non-glycosylated secreted protein of the secretoglobin superfamily. It is produced by the non-ciliated; non-mucous secretory cells that predominate in lung bronchioles (Clara cells); and other non-ciliated epithelia that communicate with the external environment. Expression is induced by steroid hormones such as estrogen; and enhanced by the non-steroid hormone prolactin. Human Uteroglobin cDNA encodes a 21 amino acid (aa) signal sequence and a 70 aa mature protein. The mature protein forms a disulfide-linked head-to-tail homodimer of 16 kDa. This homodimer is thought to form a binding pocket that binds hydrophobic ligands such as phospholipids; progesterone and retinols. Binding of fibronectin to Uteroglobin in the kidney is thought to protect against nephropathy; while binding of the lipocalin-1 receptor has been reported to suppress cancer cell motility and invasion.

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