Human UBE2J2 Recombinant Protein (RPPB2381)
- SKU:
- RPPB2381
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8N2K1
- Research Area:
- Enzymes
Description
| Product Name: | Human UBE2J2 Recombinant Protein |
| Product Code: | RPPB2381 |
| Size: | 20µg |
| Species: | Human |
| Target: | UBE2J2 |
| Synonyms: | Ubiquitin-conjugating enzyme E2 J2, ubiquitin-conjugating enzyme E2 J2 (UBC6 homolog east), Non-canonical ubiquitin-conjugating enzyme 2, ubiquitin conjugating enzyme 6, PRO2121, yeast UBC6 homolog, Ubc6p, NCUBE-2, EC 6.3.2.19. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The UBE2J2 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 1mM DTT and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSSTSS KRAPTTATQR LKQDYLRIKK DPVPYICAEP LPSNILEWHY VVRGPEMTPY EGGYYHGKLI FPREFPFKPP SIYMITPNGR FKCNTRLCLS ITDFHPDTWN PAWSVSTILT GLLSFMVEKG PTLGSIETSD FTKRQLAVQS LAFNLKDKVF CELFPEVVEE IKQKQKAQDE LSSRPQTLPL PDVVPDGETH LVQNGIQLLN GHAPGAVPNL AGLQQANRHH |
Ubiquitin-conjugating enzyme E2 J2 (UBE2J2) is a member of the ubiquitin-conjugating enzyme family. UBE2J2 catalyzes the covalent attachment of ubiquitin to other proteins. UBE2J2 is located in the membrane of the endoplasmic reticulum. UBE2J2 participates in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
UBE2J2 Human Recombinant produced in E. coli is a single polypeptide chain containing 250 amino acids (1-226) and having a molecular mass of 28.0 kDa.UBE2J2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UBE2J2: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Endoplasmic reticulum; Ubiquitin ligase; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ATP binding; ligase activity Biological Process: ER-associated protein catabolic process; protein polyubiquitination; response to unfolded protein |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N2K1 |
| NCBI GenInfo Identifier: | 251757431 |
| NCBI Gene ID: | 118424 |
| NCBI Accession: | Q8N2K1.3 |
| UniProt Secondary Accession: | Q8N2K1,Q504T9, Q96N26, Q96T84, A8MYC7, |
| UniProt Related Accession: | Q8N2K1 |
| Molecular Weight: | 259 |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 J2 |
| NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2, J2 |
| NCBI Official Symbol: | UBE2J2�� |
| NCBI Official Synonym Symbols: | NCUBE2; NCUBE-2; PRO2121�� |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 J2; yeast UBC6 homolog; ubiquitin conjugating enzyme 6; ubiquitin conjugating enzyme E2, J2; non-canonical ubiquitin-conjugating enzyme 2; ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 J2 |
| UniProt Synonym Protein Names: | Non-canonical ubiquitin-conjugating enzyme 2; NCUBE-2 |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2J2�� |
| UniProt Entry Name: | UB2J2_HUMAN |
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