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Human TXNL4A Recombinant Protein (RPPB5054)

SKU:
RPPB5054
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P83876
€309
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Description

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Product Name:Human TXNL4A Recombinant Protein
Product Code:RPPB5054
Size:10µg
Species:Human
Target:TXNL4A
Synonyms:Thioredoxin-like 4A, Spliceosomal U5 snRNP-specific 15 kDa protein, DIM1 protein homolog, HsT161, TXNL4, DIB1, U5-15kD.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TXNL4A solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 200mM NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSYMLP HLHNGWQVDQ AILSEEDRVV VIRFGHDWDP TCMKMDEVLY SIAEKVKNFA VIYLVDITEV PDFNKMYELY DPCTVMFFFR NKHIMIDLGT GNNNKINWAM EDKQEMVDII ETVYRGARKG RGLVVSPKDY STKYRY

TXNL4A is a member of the Dim protein family and has a vital part in pre-mRNA splicing. As a result of a failure to express early zygotic transcripts, deletion of the gene encoding TXNL4A in Schizosaccharomyces pombe results in embryonal lethality during gastrulation. Restricted to the nucleus, TXNL4A cooperates with hnRNP F, hnRNP H2, Cas-L and PQBP-1 to influence gene expression.

TXNL4A Human Recombinant produced in E. coli is a single polypeptide chain containing 166 amino acids (1-142) and having a molecular mass of 19.3kDa.TXNL4A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

NCBI Summary:The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
UniProt Code:P83876
NCBI GenInfo Identifier:33875918
NCBI Gene ID:10907
NCBI Accession:BC001046
UniProt Secondary Accession:P83876,O14834, B2RC18,
UniProt Related Accession:P83876
Molecular Weight:16,786 Da
NCBI Full Name:Homo sapiens thioredoxin-like 4A, mRNA
NCBI Synonym Full Names:thioredoxin like 4A
NCBI Official Symbol:TXNL4A��
NCBI Official Synonym Symbols:BMKS; DIB1; DIM1; TXNL4; SNRNP15; U5-15kD��
NCBI Protein Information:thioredoxin-like protein 4A
UniProt Protein Name:
Protein Family:Thioredoxin-like protein
UniProt Gene Name:

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