Human TPT1 Recombinant Protein (RPPB4996)
- SKU:
- RPPB4996
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P13693
Description
| Product Name: | Human TPT1 Recombinant Protein |
| Product Code: | RPPB4996 |
| Size: | 25µg |
| Species: | Human |
| Target: | TPT1 |
| Synonyms: | TCTP, Fortilin, Histamine-Releasing Factor, Translationally-controlled tumor protein, p23, HRF, Fortilin, p02, FLJ27337, TPT1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | TPT1 solution containing 20mM Tris-HCl pH-8, 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMMI IYRDLISHDE MFSDIYKIRE IADGLCLEVE GKMVSRTEGN IDDSLIGGNA SAEGPEGEGT ESTVITGVDI VMNHHLQETS FTKEAYKKYI KDYMKSIKGK LEEQRPERVK PFMTGAAEQI KHILANFKNY QFFIGENMNP DGMVALLDYR EDGVTPYMIF FKDGLEMEKC |
TPT1 takes part in calcium binding and microtubule stabilization. TPT1 is an immunoglobulin E dependent histamine-releasing factor produced by lymphocytes of atopic children and present in biologic fluids of allergic patients. TPT1 protein is similar to p23, a protein of Ehrlich ascites tumor cells, synthesized in the exponentially growing tumor. TPT1 is similar with IgE-dependent histamine releasing factor. TPT1 has a cell housekeeping function. TPT1 is involved in spermatogenesis and acts as a calcium binding protein of the human placenta that regulates calcium handling in trophoblast cells.
TPT1 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 210 amino acids (1-172 a.a.) and having a molecular mass of 23.9 kDa. TPT1 is fused to a 38 amino acid His-Tag at N-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation. |
| UniProt Protein Details: | Protein type:Calcium-binding; Microtubule-binding Chromosomal Location of Human Ortholog: 13q14 Cellular Component: multivesicular body; extracellular space; tubulin complex; cytoplasm; nucleus Molecular Function:protein binding; calcium ion binding Biological Process: regulation of apoptosis; cellular calcium ion homeostasis; response to virus; calcium ion transport; negative regulation of apoptosis |
| UniProt Code: | P13693 |
| NCBI GenInfo Identifier: | 136479 |
| NCBI Gene ID: | 7178 |
| NCBI Accession: | P13693.1 |
| UniProt Secondary Accession: | P13693,Q6YLS2, Q7Z4J4, Q8TBK7, Q96EE2, Q9UC70, B2R7E5 |
| UniProt Related Accession: | P13693 |
| Molecular Weight: | 172 |
| NCBI Full Name: | Translationally-controlled tumor protein |
| NCBI Synonym Full Names: | tumor protein, translationally-controlled 1 |
| NCBI Official Symbol: | TPT1�� |
| NCBI Official Synonym Symbols: | HRF; p02; p23; TCTP�� |
| NCBI Protein Information: | translationally-controlled tumor protein; fortilin; histamine-releasing factor |
| UniProt Protein Name: | Translationally-controlled tumor protein |
| UniProt Synonym Protein Names: | Fortilin; Histamine-releasing factor; HRF; p23 |
| Protein Family: | TPT1-like protein |
| UniProt Gene Name: | TPT1�� |
| UniProt Entry Name: | TCTP_HUMAN |
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