Human TNFRSF6B Recombinant Protein (RPPB1017)
- SKU:
- RPPB1017
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95407
- Research Area:
- Cytokines
Description
| Product Name: | Human TNFRSF6B Recombinant Protein |
| Product Code: | RPPB1017 |
| Size: | 20µg |
| Species: | Human |
| Target: | TNFRSF6B |
| Synonyms: | Tumor Necrosis Factor Receptor Superfamily, Member 6b Decoy, Decoy Receptor For Fas Ligand, Decoy Receptor 3, DCR3, M68E, M68, TR6, DJ583P15.1.1, DcR3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | TNFRSF6B protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVAETPTY PWRDAETGER LVCAQCPPGT FVQRPCRRDS PTTCGPCPPR HYTQFWNYLE RCRYCNVLCG EREEEARACH ATHNRACRCR TGFFAHAGFC LEHASCPPGA GVIAPGTPSQ NTQCQPCPPG TFSASSSSSE QCQPHRNCTA LGLALNVPGS SSHDTLCTSC TGFPLSTRVP GAEECERAVI DFVAFQDISI KRLQRLLQAL EAPEGWGPTP RAGRAALQLK LRRRLTELLG AQDGALLVRL LQALRVARMP GLERSVRERF LPVH |
TNFRSF6B is a member of the Tumor necrosis factor receptor superfamily. TNFRSF6B performs as a decoy receptor which races against death receptors for ligand binding. TNFRSF6B has a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation in addition to inducing angiogenesis via neutralization of TL1A.
TNFRSF6B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 294 amino acids (30-300aa) and having a molecular mass of 32.1kDa.TNFRSF6B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20q13.3 Cellular Component: extracellular space Molecular Function:protein binding; receptor activity Biological Process: apoptosis; negative regulation of apoptosis |
| NCBI Summary: | This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011] |
| UniProt Code: | O95407 |
| NCBI GenInfo Identifier: | 14790170 |
| NCBI Gene ID: | 8771 |
| NCBI Accession: | NP_116563.1 |
| UniProt Related Accession: | O95407 |
| Molecular Weight: | 32,680 Da |
| NCBI Full Name: | |
| NCBI Synonym Full Names: | TNF receptor superfamily member 6b |
| NCBI Official Symbol: | TNFRSF6B�� |
| NCBI Official Synonym Symbols: | M68; TR6; DCR3; M68E; DJ583P15.1.1�� |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 6B |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 6B |
| UniProt Synonym Protein Names: | Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68 |
| Protein Family: | Tumor necrosis factor receptor superfamily |
| UniProt Gene Name: | TNFRSF6B�� |
| UniProt Entry Name: | TNF6B_HUMAN |
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