The TNFRSF11A Polyclonal Antibody is a valuable tool for researchers studying TNFRSF11A, a cell surface receptor involved in immune regulation and bone metabolism. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in Western blot and immunohistochemistry applications.TNFRSF11A, also known as RANK (Receptor Activator of Nuclear Factor Kappa-B), is a key player in the regulation of osteoclast differentiation and function, making it a crucial target for studies on bone diseases such as osteoporosis and inflammatory bone loss disorders.
Additionally, TNFRSF11A has been implicated in the regulation of immune responses and inflammation, highlighting its potential role in research on autoimmune diseases and cancer.By using the TNFRSF11A Polyclonal Antibody, researchers can accurately detect and analyze TNFRSF11A expression in various cell types, providing valuable insights into its role in physiology and disease. This antibody is an essential tool for investigations in immunology, bone biology, and cancer research, paving the way for new therapeutic interventions targeting TNFRSF11A.
Product Name:
Human TNFRSF11A Polyclonal Antibody
SKU:
CAB22547
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-212 of human TNFRSF11A. (NP_003830.1).
cytosol, external side of plasma membrane, plasma membrane
Calculated MW:
66kDa
Observed MW:
100kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
Purification Method:
Affinity purification
Gene ID:
8792
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of C2C12, using Human TNFRSF11A antibody (CAB22547) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
