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Human TLR5-Strep full length protein-synthetic nanodisc (HDFP879)

SKU:
HDFP879
Size:
10μg
Target:
TLR5
Tag:
C-Flag&Strep Tag
Expression Host:
HEK293
Conjugate:
Unconjugated
€1,249

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Nanodisc Human TLR5-Strep Protein
SKU:HDFP879
Size:10μg
Target:TLR5
Tag:C-Flag&Strep Tag
Expression Host:HEK293
Conjugate:Unconjugated
Synonyms:MELIOS; SLE1; SLEB1; TIL3
Protein Families:Druggable Genome, Transmembrane.
Protein Description:Human TLR5-Strep full length protein-synthetic nanodisc
Protein Pathways:Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway.
Molecular Weight:The human full length TLR5-Strep protein has a MW of 97.8 kDa

Toll-like receptor (TLR) family plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

Uniprot ID:O60602
Formulation & Reconstitution:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Usage:Research use only

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