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Human TLR3 Polyclonal Antibody (CAB24885)

SKU:
CAB24885
$155
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Description

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Product Name:Human TLR3 Polyclonal Antibody
SKU:CAB24885
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant Protein corresponding to a sequence within amino acids 24-339 of human Human TLR3(NP_003256.1).
Sequence:STTK CTVS HEVA DCSH LKLT QVPD DLPT NITV LNLT HNQL RRLP AANF TRYS QLTS LDVG FNTI SKLE PELC QKLP MLKV LNLQ HNEL SQLS DKTF AFCT NLTE LHLM SNSI QKIK NNPF VKQK NLIT LDLS HNGL SSTK LGTQ VQLE NLQE LLLS NNKI QALK SEEL DIFA NSSL KKLE LSSN QIKE FSPG CFHA IGRL FGLF LNNV QLGP SLTE KLCL ELAN TSIR NLSL SNSQ LSTT SNTT FLGL KWTN LTML DLSY NNLN VVGN DSFA WLPQ LEYF FLEY NNIQ HLFS HSLH GLFN VRYL NLKR SFTK QSIS
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:TLR3; CD283; IIAE2; toll-like receptor 3; Human TLR3
Positive Sample:293T transfected with TLR3
Conjugate:Unconjugated
Cellular Localization:Early endosome, Endoplasmic reticulum membrane, Endosome membrane, Single-pass type I membrane protein.
Calculated MW:72kDa/103kDa
Observed MW:130kDa

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Purification Method:Affinity purification
Gene ID:7098
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and 293T cells transfected with TLR3 using Human TLR3 Rabbit pAb(CAB24885) at 1:800 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 10s.

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