Description
Product Name: | Human TLR3 Polyclonal Antibody |
SKU: | CAB24885 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 24-339 of human Human TLR3(NP_003256.1). |
Sequence: | STTK CTVS HEVA DCSH LKLT QVPD DLPT NITV LNLT HNQL RRLP AANF TRYS QLTS LDVG FNTI SKLE PELC QKLP MLKV LNLQ HNEL SQLS DKTF AFCT NLTE LHLM SNSI QKIK NNPF VKQK NLIT LDLS HNGL SSTK LGTQ VQLE NLQE LLLS NNKI QALK SEEL DIFA NSSL KKLE LSSN QIKE FSPG CFHA IGRL FGLF LNNV QLGP SLTE KLCL ELAN TSIR NLSL SNSQ LSTT SNTT FLGL KWTN LTML DLSY NNLN VVGN DSFA WLPQ LEYF FLEY NNIQ HLFS HSLH GLFN VRYL NLKR SFTK QSIS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | TLR3; CD283; IIAE2; toll-like receptor 3; Human TLR3 |
Positive Sample: | 293T transfected with TLR3 |
Conjugate: | Unconjugated |
Cellular Localization: | Early endosome, Endoplasmic reticulum membrane, Endosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 72kDa/103kDa |
Observed MW: | 130kDa |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
Purification Method: | Affinity purification |
Gene ID: | 7098 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |