Human THTPA Recombinant Protein (RPPB2318)
- SKU:
- RPPB2318
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BU02
- Research Area:
- Enzymes
Frequently bought together:
Description
| Product Name: | Human THTPA Recombinant Protein |
| Product Code: | RPPB2318 |
| Size: | 25µg |
| Species: | Human |
| Target: | THTPA |
| Synonyms: | MGC2652, THTP, THTPASE. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The THTPA 1mg/ml protein solution contains 20mM Tris-HCL buffer, pH-8, 1mM DTT and 10% Glycerol. |
| Stability: | Store THTPA at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAQGLIEVER KFLPGPGTEE RLQELGGTLE YRVTFRDTYY DTPELSLMQA DHWLRRREDS GWELKCPGAA GVLGPHTEYK ELTAEPTIVA QLCKVLRADG LGAGDVAAVL GPLGLQEVAS FVTKRSAWKL VLLGADEEEP QLRVDLDTAD FGYAVGEVEA LVHEEAEVPT ALEKIHRLSS MLGVPAQETA PAKLIVYLQR FRPQDYQRLL EVNSSRERPQ ETEDPDHCLG |
THTPA enzyme is part of the THTPase family. THTPA is localized to the cytoplasm and expressed at small quantities in a variety of tissues, including testis, uterus, prostate, bladder, lung and kidney. THTPA is a hydrolase that catalyzes the H2O-dependent hydrolysis of thiamine triphosphate (THTP) to thiamine diphosphate (THDP), the main form of thiamine within the cell. THTPA occurs as a monomer and is activated at an optimal pH of 8.5.
Recombinant Human THTPA produced in E.Coli is a single, non-glycosylated polypeptide chain containing 250 amino acids (1-230 a.a.) and having a molecular mass of 27.7 kDa. THTPA is fused to a 20 amino acid His-Tag at N-Terminus and purified by conventional chromatography techniques.
| UniProt Protein Function: | THTP: Hydrolase highly specific for thiamine triphosphate (ThTP). Belongs to the ThTPase family.Protein type: Cofactor and Vitamin Metabolism - thiamine; EC 3.6.1.28; HydrolaseChromosomal Location of Human Ortholog: 14q11.2Cellular Component: cytosolMolecular Function: hydrolase activity; magnesium ion binding; thiamin-triphosphatase activityBiological Process: dephosphorylation; thiamin and derivative metabolic process; thiamin diphosphate metabolic process; thiamin metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9BU02 |
| NCBI GenInfo Identifier: | 187607407 |
| NCBI Gene ID: | 79178 |
| NCBI Accession: | NP_001119811.1 |
| UniProt Secondary Accession: | Q9BU02,D3DS50, G3V4J3 |
| UniProt Related Accession: | Q9BU02 |
| Molecular Weight: | 12,038 Da |
| NCBI Full Name: | thiamine-triphosphatase isoform 1 |
| NCBI Synonym Full Names: | thiamine triphosphatase |
| NCBI Official Symbol: | THTPA�� |
| NCBI Official Synonym Symbols: | THTP; THTPASE�� |
| NCBI Protein Information: | thiamine-triphosphatase |
| UniProt Protein Name: | Thiamine-triphosphatase |
| UniProt Synonym Protein Names: | |
| Protein Family: | Thiamine-triphosphatase |
| UniProt Gene Name: | THTPA�� |
| UniProt Entry Name: | THTPA_HUMAN |
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