Human THRSP Recombinant Protein (RPPB4955)
- SKU:
- RPPB4955
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q92748
Description
| Product Name: | Human THRSP Recombinant Protein |
| Product Code: | RPPB4955 |
| Size: | 20µg |
| Species: | Human |
| Target: | THRSP |
| Synonyms: | Lpgp, LPGP1, S14, SPOT14, THRP, Spot 14 protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | THRSP protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMQVLTKR YPKNCLLTVM DRYAAEVHNM EQVVMIPSLL RDVQLSGPGG QAQAEAPDLY TYFTMLKAIC VDVDHGLLPR EEWQAKVAGS EENGTAETEE VEDESASGEL DLEAQFHLHF SSLHHILMHL TEKAQEVTRK YQEMTGQVW |
Thyroid Hormone Responsive (THRSP) is a member of the SPOT14 family. THRSP is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. THRSP is expressed in liver and adipocytes, specifically in lipomatous modules. In addition It is expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.
THRSP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (1-146 a.a.) and having a molecular mass of 18.9kDa.THRSP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | THRSP: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. Belongs to the SPOT14 family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 11q14.1 Cellular Component: nucleoplasm; cytosol Molecular Function:protein homodimerization activity Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; lipid metabolic process; regulation of lipid biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92748 |
| NCBI GenInfo Identifier: | 2842710 |
| NCBI Gene ID: | 7069 |
| NCBI Accession: | Q92748.1 |
| UniProt Secondary Accession: | Q92748,B2R4W7, |
| UniProt Related Accession: | Q92748 |
| Molecular Weight: | 146 |
| NCBI Full Name: | Thyroid hormone-inducible hepatic protein |
| NCBI Synonym Full Names: | thyroid hormone responsive |
| NCBI Official Symbol: | THRSP�� |
| NCBI Official Synonym Symbols: | S14; Lpgp; THRP; LPGP1; SPOT14�� |
| NCBI Protein Information: | thyroid hormone-inducible hepatic protein; SPOT14 homolog; spot 14 protein; lipogenic protein 1; thyroid hormone responsive SPOT14; thyroid hormone responsive (SPOT14 homolog, rat) |
| UniProt Protein Name: | Thyroid hormone-inducible hepatic protein |
| UniProt Synonym Protein Names: | Spot 14 protein; S14; SPOT14 |
| Protein Family: | Thyroid hormone-inducible hepatic protein |
| UniProt Gene Name: | THRSP�� |
| UniProt Entry Name: | THRSP_HUMAN |
