Human THOC7 Recombinant Protein (RPPB4952)
- SKU:
- RPPB4952
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q6I9Y2
Description
| Product Name: | Human THOC7 Recombinant Protein |
| Product Code: | RPPB4952 |
| Size: | 10µg |
| Species: | Human |
| Target: | THOC7 |
| Synonyms: | THO Complex 7, Functional Spliceosome-Associated Protein24, NIF3L1BP1, Ngg1-Interacting Factor 3-Like Protein 1-Binding Protein 1, Ngg1Interacting Factor 3 Like 1 Binding Protein 1, NIF3L1-Binding Protein 1,HTREX30, FSAP24, THO Complex 7 Homolog (Drosophila), THO Complex Subunit 7Homolog, THO Complex 7 Homolog, fSAP24, hTREX30. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | THOC7 protein solution (0. 5mg/ml) containing Phosphatebuffered saline (pH7.4) and 50% glycerol, 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGAVTDD EVIRKRLLID GDGAGDDRRI NLLVKSFIKW CNSGSQEEGYSQYQRMLSTL SQCEFSMGKT LLVYDMNLRE MENYEKIYKE IECSIAGAHE KIAECKKQIL QAKRIRKNRQEYDALAKVIQ HHPDRHETLK ELEALGKELE HLSHIKESVE DKLELRRKQF HVLLSTIHEL QQTLENDEKLSEVEEAQEAS METDPKP |
THO Complex 7, also known as THOC7, is a component of the THO subcomplex of the TREX complex which couples mRNA transcription, processing and nuclear export, and which related to spliced mRNA. THOC7 is a protein coding gene which is essential for export of polyadenylated RNA. Furthermore, THOC7 is associated with RNA transport.
THOC7 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 227 amino acids (1-204 a.a) andhaving a molecular mass of 26.1kDa.THOC7 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | THOC7: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the THOC7 family. |
| UniProt Protein Details: | Protein type:RNA splicing; Spliceosome Chromosomal Location of Human Ortholog: 3p14.1 Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus Molecular Function:nucleic acid binding; protein binding Biological Process: intronless viral mRNA export from host nucleus; mRNA 3'-end processing; mRNA export from nucleus; RNA elongation from RNA polymerase II promoter; RNA export from nucleus; termination of RNA polymerase II transcription |
| UniProt Code: | Q6I9Y2 |
| NCBI GenInfo Identifier: | 229462996 |
| NCBI Gene ID: | 80145 |
| NCBI Accession: | Q6I9Y2.3 |
| UniProt Secondary Accession: | Q6I9Y2,Q6P1L3, Q8WUF2, Q9H5H0, |
| UniProt Related Accession: | Q6I9Y2 |
| Molecular Weight: | 23,743 Da |
| NCBI Full Name: | THO complex subunit 7 homolog |
| NCBI Synonym Full Names: | THO complex 7 |
| NCBI Official Symbol: | THOC7�� |
| NCBI Official Synonym Symbols: | fSAP24; hTREX30; NIF3L1BP1�� |
| NCBI Protein Information: | THO complex subunit 7 homolog |
| UniProt Protein Name: | THO complex subunit 7 homolog |
| UniProt Synonym Protein Names: | Functional spliceosome-associated protein 24; fSAP24; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1-binding protein 1; hTREX30 |
| Protein Family: | THO complex |
| UniProt Gene Name: | THOC7�� |
| UniProt Entry Name: | THOC7_HUMAN |
