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Human TFB1M Recombinant Protein (RPPB4935)

SKU:
RPPB4935
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WVM0
€469

Description

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Product Name:Human TFB1M Recombinant Protein
Product Code:RPPB4935
Size:10µg
Species:Human
Target:TFB1M
Synonyms:Dimethyladenosine transferase 1 mitochondrial, Mitochondrial 12S rRNA dimethylase 1, Mitochondrial transcription factor B1, h-mtTFB, h-mtTFB1, hTFB1M, mtTFB1, S-adenosylmethionine-6-N'-N'-adenosyl(rRNA) dimethyltransferase 1, TFB1M, CGI-75, CGI75, mtTFB.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:TFB1M protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MQAAKQLSQN FLLDLRLTDK IVRKAGNLTN AYVYEVGPGP GGITRSILNA DVAELLVVEK DTRFIPGLQM LSDAAPGKLR IVHGDVLTFK VEKAFSESLK RPWEDDPPNV HIIGNLPFSV STPLIIKWLE NISCRDGPFV YGRTQMTLTF QKEVAERLAA NTGSKQRSRL SVMAQYLCNV RHIFTIPGQA FVPKPEVDVG VVHFTPLIQP KIEQPFKLVE KVVQNVFQFR RKYCHRGLRM LFPEAQRLES TGRLLELADI DPTLRPRQLS ISHFKSLCDV YRKMCDEDPQ LFAYNFREEL KRRKSKNEEK EEDDAENYRL

TFB1M is a member of the methyltransferase superfamily. TFB1M is a dimethyltransferase which methylates mitochondrial 12S rRNA at the conserved stem loop. The TFB1M protein also is part of the basal mitochondrial transcription complex and is required for mitochondrial gene expression. TFB1M stimulates transcription independently of the methyltransferase activity.

TFB1M Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 340 amino acids (28-346 a.a.) and having a molecular mass of 38.8kDa.TFB1M is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

NCBI Summary:The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]
UniProt Code:Q8WVM0
NCBI GenInfo Identifier:17389499
NCBI Gene ID:51106
NCBI Accession:BC017788
UniProt Secondary Accession:Q8WVM0,Q05DR0, Q9Y384,
UniProt Related Accession:Q8WVM0
Molecular Weight:39,543 Da
NCBI Full Name:Homo sapiens transcription factor B1, mitochondrial, mRNA
NCBI Synonym Full Names:transcription factor B1, mitochondrial
NCBI Official Symbol:TFB1M��
NCBI Official Synonym Symbols:CGI75; mtTFB; CGI-75; mtTFB1��
NCBI Protein Information:dimethyladenosine transferase 1, mitochondrial
UniProt Protein Name:
Protein Family:Dimethyladenosine transferase
UniProt Gene Name:

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