Human TBC1D1 Recombinant Protein (RPPB4916)
- SKU:
- RPPB4916
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q86TI0
Description
| Product Name: | Human TBC1D1 Recombinant Protein |
| Product Code: | RPPB4916 |
| Size: | 20µg |
| Species: | Human |
| Target: | TBC1D1 |
| Synonyms: | TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1, KIAA1108,TBC, TBC1, TBC1 Domain Family Member 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | TBC1D1 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSEEEAF KMLKFLMFDM GLRKQYRPDM IILQIQMYQL SRLLHDYHRDLYNHLEEHEI GPSLYAAPWF LTMFASQFPL GFVARVFDMI FLQGTEVIFK VALSLLGSHK PLILQHENLETIVDFIKSTL PNLGLVQMEK TINQVFEMDI AKQLQAYEVE YHVLQEELID SSPLSDNQRM DKLEKTNSSL RKQNLDLLEQ LQVANGRIQSLEATIEKLLS SESKLKQAML TLELERSALL QTVEELRRRS AEPSDREPEC TQPEPTGD |
TBC1D1 belongs to a family of proteins sharing a 180-200 a.a TBC domain having a role in regulating cell growth and differentiation of various tissues. These proteins share significant homology with TRE2, yeast Bub2, and CDC16. TBC1D1 function as a GTPase-activating protein for Rab family proteins. TBC1D1 is involved in the trafficking and translocation of GLUT4-containing vesicles. Among the diseases associated with TBC1D1 are tuberculous meningitis, and meningitis.
TBC1D1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-265 a.a) and having a molecular mass of 33.2kDa.TBC1D1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TBC1D1: a putative GTPase activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. |
| UniProt Protein Details: | Protein type:GAPs; Ubiquitin-specific protease; GAPs, Rab Chromosomal Location of Human Ortholog: 4p14 Cellular Component: cytosol; endomembrane system; intracellular Molecular Function:GTPase activator activity; protein binding; Rab GTPase binding Biological Process: intracellular protein transport; regulation of vesicle fusion |
| NCBI Summary: | TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q86TI0 |
| NCBI GenInfo Identifier: | 116242816 |
| NCBI Gene ID: | 23216 |
| NCBI Accession: | Q86TI0.2 |
| UniProt Secondary Accession: | Q86TI0,Q96K82, Q9UPP4, B7Z3D9, E9PGH8, |
| UniProt Related Accession: | Q86TI0 |
| Molecular Weight: | 131,378 Da |
| NCBI Full Name: | TBC1 domain family member 1 |
| NCBI Synonym Full Names: | TBC1 domain family member 1 |
| NCBI Official Symbol: | TBC1D1�� |
| NCBI Official Synonym Symbols: | TBC; TBC1�� |
| NCBI Protein Information: | TBC1 domain family member 1 |
| UniProt Protein Name: | TBC1 domain family member 1 |
| Protein Family: | TBC1 domain family |
| UniProt Gene Name: | TBC1D1�� |
| UniProt Entry Name: | TBCD1_HUMAN |
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