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Human SYT13 Recombinant Protein (RPPB4892)

SKU:
RPPB4892
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q7L8C5
€309
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Description

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Product Name:Human SYT13 Recombinant Protein
Product Code:RPPB4892
Size:20µg
Species:Human
Target:SYT13
Synonyms:Synaptotagmin XIII, KIAA1427, synaptotagmin-13, sytXIII.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The SYT13 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT, 1mM PMSF, 1mM EDTA and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSCRHMHPK KGLLPRDQDP DLEKAKPSLL GSAQQFNVKK STEPVQPRAL LKFPDIYGPR PAVTAPEVIN YADYSLRSTE EPTAPASPQP PNDSRLKRQV TEELFILPQN GVVEDVCVME TWNPEKAASW NQAPKLHYCL DYDCQKAELF VTRLEAVTSN HDGGCDCYVQ GSVANRTGSV EAQTALKKRQ LHTTWEEGLV LPLAEEELPT ATLTLTLRTC DRFSRHSVAG ELRLGLDGTS VPLGAAQWGE LKTSAKEPSA GAGEVLLSIS YLPAANRLLV VLIKAKNLHS NQSKELLGKD VSVKVTLKHQ ARKLKKKQTK RAKHKINPVW NEMIMFELPD DLLQASSVEL EVLGQDDSGQ SCALGHCSLG LHTSGSERSH WEEMLKNPRR QIAMWHQLHL

SYT13 belongs to the great synaptotagmin protein family which contain 2 domains: cytoplasmic C terminus with two tandem C2 domains (C2A and C2B) and extracellular N-terminal transmembrane domain. Synaptotogmin family members have dissimilar biochemical properties and developmental profiles, and patterns of tissue distribution. Additionally, Synaptotogmins formulate homo- and heteromeric complexes with each other. Synaptotagmins operate as membrane traffickers in multicellular organisms.

SYT13 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 420 amino acids (30-426) and having a molecular mass of 46.5kDa.SYT13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SYT13: May be involved in transport vesicle docking to the plasma membrane. Belongs to the synaptotagmin family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: intracellular membrane-bound organelle; plasma membrane; transport vesicle

Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; vesicle fusion

NCBI Summary:This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q7L8C5
NCBI GenInfo Identifier:74749900
NCBI Gene ID:57586
NCBI Accession:Q7L8C5.1
UniProt Secondary Accession:Q7L8C5,Q9BQS3, Q9H041, Q9P2C0, A8K4P4, D3DQP1,
UniProt Related Accession:Q7L8C5
Molecular Weight:47kDa
NCBI Full Name:Synaptotagmin-13
NCBI Synonym Full Names:synaptotagmin 13
NCBI Official Symbol:SYT13��
NCBI Protein Information:synaptotagmin-13
UniProt Protein Name:Synaptotagmin-13
UniProt Synonym Protein Names:Synaptotagmin XIII; SytXIII
Protein Family:Synaptotagmin
UniProt Gene Name:SYT13��

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