Human SULT1B1 Recombinant Protein (RPPB2293)
- SKU:
- RPPB2293
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43704
- Research Area:
- Enzymes
Description
| Product Name: | Human SULT1B1 Recombinant Protein |
| Product Code: | RPPB2293 |
| Size: | 20µg |
| Species: | Human |
| Target: | SULT1B1 |
| Synonyms: | Sulfotransferase family cytosolic 1B member 1, Thyroid hormone sulfotransferase, Sulfotransferase 1B1, Sulfotransferase 1B2, ST1B1, EC 2.8.2.-, SULT1B2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SULT1B1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMLSPKD ILRKDLKLVH GYPMTCAFAS NWEKIEQFHS RPDDIVIATY PKSGTTWVSE IIDMILNDGD IEKCKRGFIT EKVPMLEMTL PGLRTSGIEQ LEKNPSPRIV KTHLPTDLLP KSFWENNCKM IYLARNAKDV SVSYYHFDLM NNLQPFPGTW EEYLEKFLTG KVAYGSWFTH VKNWWKKKEE HPILFLYYED MKENPKEEIK KIIRFLEKNL NDEILDRIIH HTSFEVMKDN PLVNYTHLPT TVMDHSKSPF MRKGTAGDWK NYFTVAQNEK FDAIYETEMS KTALQFRTEI |
SULT1B1 enzyme in humans is encoded by the SULT1B1 gene. SULT1B1 holds a binding site for 3-prime-phosphoadenosine 5-prime-phosphosulfate, a sulfate donor, in addition to a cysteine residue conserved in the ST1 gene family of sulfotransferases. Sulfotransferases like SULT1B1 catalyze the biotransformation of a great amount of endogenous amalgams such as bile acids, neurotransmitters, steroids, and thyroid hormones, in addition to drugs and xenobiotics.
SULT1B1 Human Recombinant produced in�E. coli is a single polypeptide chain containing 320 amino acids (1-296) and having a molecular mass of 37.4kDa.SULT1B1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SULT1B1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. Belongs to the sulfotransferase 1 family. |
| UniProt Protein Details: | Protein type:EC 2.8.2.-; Transferase Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: cytosol Molecular Function:sulfotransferase activity; aryl sulfotransferase activity Biological Process: steroid metabolic process; biogenic amine metabolic process; epithelial cell differentiation; flavonoid metabolic process; xenobiotic metabolic process; sulfation; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; thyroid hormone metabolic process; phenol metabolic process |
| NCBI Summary: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43704 |
| NCBI GenInfo Identifier: | 57013032 |
| NCBI Gene ID: | 27284 |
| NCBI Accession: | O43704.2 |
| UniProt Secondary Accession: | O43704,O15497, Q96FI1, Q9UK34, |
| UniProt Related Accession: | O43704 |
| Molecular Weight: | 296 |
| NCBI Full Name: | Sulfotransferase family cytosolic 1B member 1 |
| NCBI Synonym Full Names: | sulfotransferase family, cytosolic, 1B, member 1 |
| NCBI Official Symbol: | SULT1B1�� |
| NCBI Official Synonym Symbols: | ST1B1; ST1B2; SULT1B2�� |
| NCBI Protein Information: | sulfotransferase family cytosolic 1B member 1; sulfotransferase 1B1; sulfotransferase 1B2; thyroid hormone sulfotransferase |
| UniProt Protein Name: | Sulfotransferase family cytosolic 1B member 1 |
| UniProt Synonym Protein Names: | Sulfotransferase 1B2; ST1B2; Thyroid hormone sulfotransferase |
| Protein Family: | Sulfotransferase family cytosolic |
| UniProt Gene Name: | SULT1B1�� |
| UniProt Entry Name: | ST1B1_HUMAN |
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