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Human STMN2 Recombinant Protein (RPPB4850)

SKU:
RPPB4850
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q93045
€309
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Description

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Product Name:Human STMN2 Recombinant Protein
Product Code:RPPB4850
Size:10µg
Species:Human
Target:STMN2
Synonyms:SCG10, STMB2, SCGN10, AI159727, STMN-2, Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10, STMN2, SGC10, stathmin-like 2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The STMN2 protein solution contains 50mM Tris-HCl, pH-7.5 and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MDMEVKQINK RASGQAFELI LKPPSPISEA PRTLASPKKK DLSLEEIQKK LEAAEERRKS QEAQVLKQLA EKREHEREVL QKALEENNNF SKMAEEKLIL KMEQIKENRE ANLAAIIERL QEKERHAAEV RRNKELQVEL SG

STMN2 is a neuronal growth-associated protein which shares a majority of its amino acid sequence with the phosphoprotein stathmin. STMN2 is involved in neuronal differentiation and in modulating membrane interaction with the cytoskeleton through neurite outgrowth. STMN2 is necessary for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells. SCG10 is a novel indicator of osteogenesis and osteoblast that takes part in the regulation of the adipocyte/osteoblast balance. STMN2 plays a role as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization.

Recombinant Human Stathmin Like-2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 142 amino acids (39-179 a.a) and having a molecular mass of 16.4 kDa. STMN2 is purified by conventional chromatography techniques.

UniProt Protein Function:STMN2: a cytoskeletal protein that may play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth. Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Neuron specific.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: cell soma; cytoplasm; growth cone; lamellipodium; neuron projection; perinuclear region of cytoplasm

Molecular Function:calcium-dependent protein binding; protein binding; tubulin binding

Biological Process: negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization; positive regulation of microtubule depolymerization

NCBI Summary:This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
UniProt Code:Q93045
NCBI GenInfo Identifier:51704330
NCBI Gene ID:11075
NCBI Accession:Q93045.3
UniProt Secondary Accession:Q93045,O14952, Q6PK68, A8K9M2, G3V110,
UniProt Related Accession:Q93045
Molecular Weight:21,802 Da
NCBI Full Name:Stathmin-2
NCBI Synonym Full Names:stathmin 2
NCBI Official Symbol:STMN2��
NCBI Official Synonym Symbols:SCG10; SCGN10��
NCBI Protein Information:stathmin-2
UniProt Protein Name:Stathmin-2
UniProt Synonym Protein Names:Superior cervical ganglion-10 protein; Protein SCG10
Protein Family:Stathmin
UniProt Gene Name:STMN2��
UniProt Entry Name:STMN2_HUMAN

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