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Human STK17A Recombinant Protein (RPPB2654)

SKU:
RPPB2654
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UEE5
Research Area:
Enzymes
€469
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Description

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Product Name:Human STK17A Recombinant Protein
Product Code:RPPB2654
Size:10µg
Species:Human
Target:STK17A
Synonyms:DRAK1, Serine/threonine-protein kinase 17A, DAPkinase-related apoptosis-inducing protein kinase 1, STK17A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:STK17A protein solution (0.5mg/ml) contains 20mM Tris-HClbuffer (pH 8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSGRELGRG KFAVVRKCIK KDSGKEFAAK FMRKRRKGQD CRMEIIHEIAVLELAQDNPW VINLHEVYET ASEMILVLEY AAGGEIFDQC VADREEAFKE KDVQRLMRQI LEGVHFLHTRDVVHLDLKPQ NILLTSESPL GDIKIVDFGL SRILKNSEEL REIMGTPEYV APEILSYDPI SMATDMWSIGVLTYVMLTGI SPFLGNDKQE TFLNISQMNL SYSEEEFDVL SESAVDFIRT LLVKKPEDRA TAEECLKHPW L

STK17A belongs to the DAPkinase-associated apoptosis-inducing protein kinase family and encodes anautophosphorylated nuclear protein with a protein kinase domain. STK17A acts asa positive regulator of apoptosis. STK17A is greatly expressed in the placentawith lower levels in the heart, lung, skeletal muscle, kidney and pancreas.

STK17A Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 281 amino acids (64-321 a.a) andhaving a molecular mass of 31.9kDa.STK17A is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:DRAK1: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; DAPK familyChromosomal Location of Human Ortholog: 7p13Cellular Component: nucleusMolecular Function: protein serine/threonine kinase activity; ATP bindingBiological Process: apoptosis; positive regulation of apoptosis; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UEE5
NCBI GenInfo Identifier:109255245
NCBI Gene ID:9263
NCBI Accession:NP_004751.2
UniProt Secondary Accession:Q9UEE5,Q8IVC8, A4D1V6
UniProt Related Accession:Q9UEE5
Molecular Weight:46,558 Da
NCBI Full Name:serine/threonine-protein kinase 17A
NCBI Synonym Full Names:serine/threonine kinase 17a
NCBI Official Symbol:STK17A��
NCBI Official Synonym Symbols:DRAK1��
NCBI Protein Information:serine/threonine-protein kinase 17A; DAP kinase-related apoptosis-inducing protein kinase 1; death-associated protein kinase-related 1; serine/threonine kinase 17a (apoptosis-inducing)
UniProt Protein Name:Serine/threonine-protein kinase 17A
UniProt Synonym Protein Names:DAP kinase-related apoptosis-inducing protein kinase 1
Protein Family:
UniProt Gene Name:STK17A��
UniProt Entry Name:ST17A_HUMAN

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