Human SRR Recombinant Protein (RPPB2284)
- SKU:
- RPPB2284
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9GZT4
- Research Area:
- Enzymes
Description
| Product Name: | Human SRR Recombinant Protein |
| Product Code: | RPPB2284 |
| Size: | 5µg |
| Species: | Human |
| Target: | SRR |
| Synonyms: | Serine racemase, D-serine ammonia-lyase, D-serine dehydratase, L-serine ammonia-lyase, L-serine dehydratase, SRR, ILV1, ISO1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SRR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMCAQYC ISFADVEKAH INIRDSIHLT PVLTSSILNQ LTGRNLFFKC ELFQKTGSFK IRGALNAVRS LVPDALERKP KAVVTHSSGN HGQALTYAAK LEGIPAYIVV PQTAPDCKKL AIQAYGASIV YCEPSDESRE NVAKRVTEET EGIMVHPNQE PAVIAGQGTI ALEVLNQVPL VDALVVPVGG GGMLAGIAIT VKALKPSVKV YAAEPSNADD CYQSKLKGKL MPNLYPPETI ADGVKSSIGL NTWPIIRDLV DDIFTVTEDE IKCATQLVWE RMKLLIEPTA GVGVAAVLSQ HFQTVSPEVK NICIVLSGGN VDLTSSITWV KQAERPASYQ SVSV |
Serine racemase (SRR) is an enzyme which generates D-serine from L-serine. D-serine functions as a neuronal signaling molecule by activating NMDA receptors in the brain. Mammalian SRR is a pyridoxal 5'-phosphate dependent enzyme which catalyzes both the racemization of L-serine to D-serine and also the elimination of water from L-serine, producing pyruvate and ammonia. The SRR enzyme is physiologically stimulated by divalent cations (e.g., magnesium) and is allosterically activated by the magnesium/ATP complex.
SRR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 364 amino acids (1-340) and having a molecular mass of 39.1kDa.SRR is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. |
| UniProt Code: | Q9GZT4 |
| NCBI GenInfo Identifier: | 58200415 |
| NCBI Gene ID: | 63826 |
| NCBI Accession: | AAW66463.1 |
| UniProt Secondary Accession: | Q9GZT4,Q6IA55, D3DTI5, |
| UniProt Related Accession: | Q9GZT4 |
| Molecular Weight: | 36,566 Da |
| NCBI Full Name: | serine racemase, partial |
| NCBI Synonym Full Names: | serine racemase |
| NCBI Official Symbol: | SRR�� |
| NCBI Official Synonym Symbols: | ILV1; ISO1�� |
| NCBI Protein Information: | serine racemase |
| UniProt Protein Name: | Serine racemase |
| UniProt Synonym Protein Names: | D-serine ammonia-lyase; D-serine dehydratase (EC:4.3.1.18By similarityManual assertion inferred from sequence similarity toiUniProtKB:Q9QZX7� (SRR_MOUSE)); L-serine ammonia-lyase; L-serine dehydratase (EC:4.3.1.17By similarityManual assertion inferred from sequence similarity toiUniProtKB:Q9QZX7� (SRR_MOUSE)) |
| Protein Family: | Probable serine racemase |
| UniProt Gene Name: | SRR�� |
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