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Human SRM Recombinant Protein (RPPB2283)

SKU:
RPPB2283
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P19623
Research Area:
Enzymes
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Description

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Product Name:Human SRM Recombinant Protein
Product Code:RPPB2283
Size:20µg
Species:Human
Target:SRM
Synonyms:Spermidine synthase, SPDSY, Putrescine aminopropyltransferase, SRM, SPS1, SRML1, PAPT.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SRM solution (1 mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 10% glycerol, 2mM DTT and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEPGPDGPAA SGPAAIREGW FRETCSLWPG QALSLQVEQL LHHRRSRYQD ILVFRSKTYG NVLVLDGVIQ CTERDEFSYQ EMIANLPLCS HPNPRKVLII GGGDGGVLRE VVKHPSVESV VQCEIDEDVI QVSKKFLPGM AIGYSSSKLT LHVGDGFEFM KQNQDAFDVI ITDSSDPMGP AESLFKESYY QLMKTALKED GVLCCQGECQ WLHLDLIKEM RQFCQSLFPV VAYAYCTIPT YPSGQIGFML CSKNPSTNFQ EPVQPLTQQQ VAQMQLKYYN SDVHRAAFVL PEFARKALND VS

SRM is an enzyme which catalyzes the transfer of the propylamine group from S-adenosylmethioninamine to putrescine in the biosynthesis of spermidine. The polyamines putrescine, spermine and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. The SRM protein is one of four enzymes in the polyamine-biosynthetic pathway and completes the final step of spermidine biosynthesis.

SRM Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 322 amino acids (1-302 a.a.) and having a molecular mass of 36kDa. The SRM is purified by proprietary chromatographic techniques.

UniProt Protein Function:SRM: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine. Belongs to the spermidine/spermine synthase family.
UniProt Protein Details:

Protein type:Other Amino Acids Metabolism - glutathione; Amino Acid Metabolism - cysteine and methionine; Transferase; EC 2.5.1.16; Amino Acid Metabolism - arginine and proline; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 1p36-p22

Cellular Component: cytosol

Molecular Function:protein binding; protein homodimerization activity; spermidine synthase activity

Biological Process: polyamine metabolic process; spermidine biosynthetic process

NCBI Summary:The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
UniProt Code:P19623
NCBI GenInfo Identifier:134811
NCBI Gene ID:6723
NCBI Accession:P19623.1
UniProt Secondary Accession:P19623,Q15511, B1AKP9,
UniProt Related Accession:P19623
Molecular Weight:33,825 Da
NCBI Full Name:Spermidine synthase
NCBI Synonym Full Names:spermidine synthase
NCBI Official Symbol:SRM��
NCBI Official Synonym Symbols:PAPT; SPS1; SPDSY; SRML1��
NCBI Protein Information:spermidine synthase
UniProt Protein Name:Spermidine synthase
UniProt Synonym Protein Names:Putrescine aminopropyltransferase
UniProt Gene Name:SRM��
UniProt Entry Name:SPEE_HUMAN

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