Human SNRPG Recombinant Protein (RPPB4762)
- SKU:
- RPPB4762
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P62308
Description
| Product Name: | Human SNRPG Recombinant Protein |
| Product Code: | RPPB4762 |
| Size: | 10µg |
| Species: | Human |
| Target: | SNRPG |
| Synonyms: | Small nuclear ribonucleoprotein G, snRNP-G, Sm protein G, Sm-G, SmG, SNRPG, PBSCG, MGC117317. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SNRPG solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT SGQQNNIGMV VIRGNSIIML EALERV |
Small nuclear ribonucleoprotein polypeptide G (SNRPG) is a member of the snRNP Sm proteins family. There are at least 7 isoforms, B/B, E, F, G, D1, D2, and D3. This class of common proteins has a vital role in the biogenesis of the snRNPs. The human Sm G genes are mapped to chromosomes 2. Furthermore, these proteins represent the major targets for the supposed anti-Sm auto-antibodies which are diagnostic for SLE (systemic lupus erythematosus). One class of these autoantibodies reacts specifically with native Sm E-F-G complexes.
SNRPG Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 96 amino acids (1-76 a.a.) and having a molecular mass of 10.6kDa. The SNRPG is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | snRNP G: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. |
| UniProt Protein Details: | Protein type:RNA-binding; Spliceosome; RNA splicing Chromosomal Location of Human Ortholog: 2p13.3 Cellular Component: cytosol; nucleoplasm; snRNP U1; snRNP U2; snRNP U5; spliceosome; U12-dependent spliceosome Molecular Function:protein binding; RNA binding Biological Process: histone mRNA metabolic process; nuclear import; nuclear mRNA splicing, via spliceosome; RNA splicing; spliceosomal snRNP biogenesis; termination of RNA polymerase II transcription |
| NCBI Summary: | The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P62308 |
| NCBI GenInfo Identifier: | 59800216 |
| NCBI Gene ID: | 6637 |
| NCBI Accession: | P62308.1 |
| UniProt Secondary Accession: | P62308,Q15357, Q6IB86, D6W5G6, |
| UniProt Related Accession: | P62308 |
| Molecular Weight: | 8,496 Da |
| NCBI Full Name: | Small nuclear ribonucleoprotein G |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein polypeptide G |
| NCBI Official Symbol: | SNRPG�� |
| NCBI Official Synonym Symbols: | SMG; Sm-G�� |
| NCBI Protein Information: | small nuclear ribonucleoprotein G |
| UniProt Protein Name: | Small nuclear ribonucleoprotein G |
| UniProt Synonym Protein Names: | Sm protein G; Sm-G; SmG |
| Protein Family: | Small nuclear ribonucleoprotein |
| UniProt Gene Name: | SNRPG�� |
| UniProt Entry Name: | RUXG_HUMAN |
