Human SNRPA1 Recombinant Protein (RPPB4749)
- SKU:
- RPPB4749
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P09661
Description
| Product Name: | Human SNRPA1 Recombinant Protein |
| Product Code: | RPPB4749 |
| Size: | 5µg |
| Species: | Human |
| Target: | SNRPA1 |
| Synonyms: | U2 small nuclear ribonucleoprotein A', U2 snRNP A', SNRPA1, Lea1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SNRPA1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.2M NaCl,2mM DTT and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MVKLTAELIE QAAQYTNAVR DRELDLRGYK IPVIENLGAT LDQFDAIDFS DNEIRKLDGF PLLRRLKTLL VNNNRICRIG EGLDQALPCL TELILTNNSL VELGDLDPLA SLKSLTYLSI LRNPVTNKKH YRLYVIYKVP QVRVLDFQKV KLKERQEAEK MFKGKRGAQL AKDIARRSKT FNPGAGLPTD KKKGGPSPGD VEAIKNAIAN ASTLAEVERL KGLLQSGQIP GRERRSGPTD DGEEEMEEDT VTNGS |
U2 small nuclear ribonucleoprotein A (SNRPA1), a 255 amino acid protein, is a component of the U2 snRNP which forms a complex with U2 snRNP B (U2B). U2 snRNP A and U2 snRNP B form together a complex which binds to the U2 snRNA hairpin IV. The configuration of the U2 snRNP A/U2 snRNP B dimer and the delicate variations of a few key residues regulate the snRNP-RNA-binding specificity.
SNRPA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 275 amino acids (1-255 a.a.) and having a molecular mass of 30.5kDa. SNRPA1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | snRNP A': This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Belongs to the U2 small nuclear ribonucleoprotein A family. |
| UniProt Protein Details: | Protein type:RNA splicing; RNA-binding; Spliceosome Chromosomal Location of Human Ortholog: 15q26.3 Cellular Component: nuclear speck; nucleoplasm; small nuclear ribonucleoprotein complex; snRNP U2; spliceosome Molecular Function:protein binding; RNA binding; U2 snRNA binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing |
| UniProt Code: | P09661 |
| NCBI GenInfo Identifier: | 31077165 |
| NCBI Gene ID: | 6627 |
| NCBI Accession: | P09661.2 |
| UniProt Secondary Accession: | P09661,Q8TBD2, B2R5I6, |
| UniProt Related Accession: | P09661 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | U2 small nuclear ribonucleoprotein A' |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein polypeptide A' |
| NCBI Official Symbol: | SNRPA1�� |
| NCBI Official Synonym Symbols: | Lea1�� |
| NCBI Protein Information: | U2 small nuclear ribonucleoprotein A' |
| UniProt Protein Name: | U2 small nuclear ribonucleoprotein A' |
| UniProt Gene Name: | SNRPA1�� |
