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Human SNAI2 Recombinant Protein (RPPB4721)

SKU:
RPPB4721
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43623
€309
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Description

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Product Name:Human SNAI2 Recombinant Protein
Product Code:RPPB4721
Size:20µg
Species:Human
Target:SNAI2
Synonyms:Snail Family Zinc Finger 2, SLUG, Protein Snail Homolog 2, WS2D, Slug Homolog, Zinc Finger Protein (Chicken), Slug (Chicken Homolog), Zinc Finger Protein, Neural Crest Transcription Factor SLUG, Neural Crest Transcription Factor Slug, Snail Homolog 2 (Drosophila), Zinc Finger Protein SNAI2, Snail Homolog 2, SLUGH1, SNAIL2, SLUGH, SNAI2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SNAI2 protein solution (0.5mg/ml) containing 20mM Tris-HCl Buffer (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPRSFLV KKHFNASKKP NYSELDTHTV IISPYLYESY SMPVIPQPEI LSSGAYSPIT VWTTAAPFHA QLPNGLSPLS GYSSSLGRVS PPPPSDTSSK DHSGSESPIS DEEERLQSKL SDPHAIEAEK FQCNLCNKTY STFSGLAKHK QLHCDAQSRK SFSCKYCDKE YVSLGALKMH IRTHTLPCVC KICGKAFSRP WLLQGHIRTH TGEKPFSCPH CNRAFADRSN LRAHLQTHSD VKKYQCKNCS KTFSRMSLLH KHEESGCCVA H

Snail Family Zinc Finger 2 also knownas SNAI2 is a member of the snail C2H2-type zinc-finger protein family. SNAI2acts as a transcriptional repressor which binds to E-box motifs and is as welllikely to repress E-cadherin transcription in breast carcinoma. SNAI2 isimplicated in epithelial-mesenchymal transitions furthermore, it hasantiapoptotic activity.

SNAI2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 291 amino acids (1-268 a.a) and having a molecular mass of 32.4kDa.SNAI2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Snail2: Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. Belongs to the snail C2H2-type zinc-finger protein family.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Transcription factor; Apoptosis; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q11

Cellular Component: cytoplasm; nuclear chromatin; nucleus

Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; metal ion binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; substrate-bound cell migration, cell release from substrate; Notch signaling pathway; neural crest cell development; regulation of osteoblast differentiation; negative regulation of chondrocyte differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; sensory perception of sound; pigmentation; white fat cell differentiation; positive regulation of fat cell differentiation; epithelial to mesenchymal transition; positive regulation of histone acetylation; negative regulation of cell adhesion mediated by integrin; regulation of chemokine production; positive regulation of cell migration

Disease: Waardenburg Syndrome, Type 2d; Piebald Trait

NCBI Summary:This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
UniProt Code:O43623
NCBI GenInfo Identifier:11134406
NCBI Gene ID:6591
NCBI Accession:O43623.1
UniProt Related Accession:O43623
Molecular Weight:
NCBI Full Name:Zinc finger protein SNAI2
NCBI Synonym Full Names:snail family transcriptional repressor 2
NCBI Official Symbol:SNAI2��
NCBI Official Synonym Symbols:SLUG; WS2D; SLUGH; SLUGH1; SNAIL2��
NCBI Protein Information:zinc finger protein SNAI2
UniProt Protein Name:Zinc finger protein SNAI2
UniProt Synonym Protein Names:Neural crest transcription factor Slug; Protein snail homolog 2
UniProt Gene Name:SNAI2��
UniProt Entry Name:SNAI2_HUMAN

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