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Human SLPI Recombinant Protein (RPPB4709)

SKU:
RPPB4709
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P03973
€309
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Description

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Product Name:Human SLPI Recombinant Protein
Product Code:RPPB4709
Size:10µg
Species:Human
Target:SLPI
Synonyms:Antileukoproteinase, ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4, WAP four-disulfide core domain protein 4, Protease inhibitor WAP4, Seminal proteinase inhibitor, Mucus proteinase inhibitor.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:SLPI Human solution containing 20mM Tris-HCl pH-8.0, 2mM DTT, 0.1M NaCl & 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSGKSFKAGV CPPKKSAQCL RYKKPECQSD WQCPGKKRCC PDTCGIKCLD PVDTPNPTRR KPGKCPVTYG QCLMLNPPNF CEMDGQCKRD LKCCMGMCGK SCVSPVKA

SLPI is a secreted inhibitor which guards epithelial tissues from serine proteases. SLPI is localized in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. SLPI inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. SLPI protein has broad-spectrum anti-biotic activity. SLPI is an acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. SLPI prevents elastase-mediated damage to oral and mucosal tissues.

SLPI Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids (26-132 a.a.) and having a molecular mass of 14 kDa. The SLPI is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:SLPI: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.
UniProt Protein Details:

Protein type:Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: extracellular matrix; extracellular space

Molecular Function:endopeptidase inhibitor activity; enzyme binding; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: antibacterial humoral response; immune response; innate immune response; negative regulation of protein binding; negative regulation of viral genome replication; response to lipopolysaccharide

NCBI Summary:This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
UniProt Code:P03973
NCBI GenInfo Identifier:113636
NCBI Gene ID:6590
NCBI Accession:P03973.2
UniProt Secondary Accession:P03973,P07757, B2R5H8,
UniProt Related Accession:P03973
Molecular Weight:14,326 Da
NCBI Full Name:Antileukoproteinase
NCBI Synonym Full Names:secretory leukocyte peptidase inhibitor
NCBI Official Symbol:SLPI��
NCBI Official Synonym Symbols:ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I��
NCBI Protein Information:antileukoproteinase
UniProt Protein Name:Antileukoproteinase
UniProt Synonym Protein Names:BLPI; HUSI-1
Protein Family:Antileukoproteinase
UniProt Gene Name:SLPI��
UniProt Entry Name:SLPI_HUMAN

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