Human SIX6 Recombinant Protein (RPPB4699)
- SKU:
- RPPB4699
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95475
Description
| Product Name: | Human SIX6 Recombinant Protein |
| Product Code: | RPPB4699 |
| Size: | 20µg |
| Species: | Human |
| Target: | SIX6 |
| Synonyms: | Homeobox protein SIX6, Homeodomain protein OPTX2, Optic homeobox 2, Sine oculis homeobox homolog 6, SIX6, OPTX2, SIX9, OPTX2, MCOPCT2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SIX6 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol, 5mM DTT and 2mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMFQLPIL NFSPQQVAGV CETLEESGDV ERLGRFLWSL PVAPAACEAL NKNESVLRAR AIVAFHGGNY RELYHILENH KFTKESHAKL QALWLEAHYQ EAEKLRGRPL GPVDKYRVRK KFPLPRTIWD GEQKTHCFKE RTRNLLREWY LQDPYPNPSK KRELAQATGL TPTQVGNWFK NRRQRDRAAA AKNRLQQQVL SQGSGRALRA EGDGTPEVLG VATSPAASLS SKAATSAISI TSSDSECDI |
SIX Homeobox 6 (SIX6) is a member of the SIX/Sine oculis homeobox family contains 1 homeobox DNA-binding domain. The SIX6 protein is essential in embryonic development by providing necessary instructions for the formation of the forebrain and eye development. SIX6 is expressed in the developing and adult retina, hypothalamic and the pituitary regions. SIX6 gene defects are the cause of microphthalmia isolated with cataract type 2.
SIX6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 269 amino acids (1-246 a.a) and having a molecular mass of 30.1kDa.SIX6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SIX6: May be involved in eye development. Defects in SIX6 are the cause of microphthalmia isolated with cataract type 2 (MCOPCT2). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present. Belongs to the SIX/Sine oculis homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 14q23.1 Biological Process: organ morphogenesis; visual perception Disease: Microphthalmia, Isolated, With Cataract 2; Microphthalmia, Syndromic 3 |
| NCBI Summary: | The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95475 |
| NCBI GenInfo Identifier: | 115502450 |
| NCBI Gene ID: | 4990 |
| NCBI Accession: | O95475.2 |
| UniProt Secondary Accession: | O95475,Q6NT42, Q9P1X8, |
| UniProt Related Accession: | O95475 |
| Molecular Weight: | 27,687 Da |
| NCBI Full Name: | Homeobox protein SIX6 |
| NCBI Synonym Full Names: | SIX homeobox 6 |
| NCBI Official Symbol: | SIX6�� |
| NCBI Official Synonym Symbols: | Six9; ODRMD; OPTX2; MCOPCT2�� |
| NCBI Protein Information: | homeobox protein SIX6 |
| UniProt Protein Name: | Homeobox protein SIX6 |
| UniProt Synonym Protein Names: | Homeodomain protein OPTX2; Optic homeobox 2; Sine oculis homeobox homolog 6 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | SIX6�� |
| UniProt Entry Name: | SIX6_HUMAN |
