Human SIRT3 Recombinant Protein (RPPB4693)
- SKU:
- RPPB4693
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NTG7
Description
| Product Name: | Human SIRT3 Recombinant Protein |
| Product Code: | RPPB4693 |
| Size: | 10µg |
| Species: | Human |
| Target: | SIRT3 |
| Synonyms: | Sirtuin 3, SIR2-like protein 3, Sir2-like 3, NAD-dependent deacetylase sirtuin-3, mitochondrial. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The SIRT3 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 1mM DTT, 0.1M NaCl, 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSDKGKLSLQ DVAELIRARA CQRVVVMVGA GISTPSGIPD FRSPGSGLYS NLQQYDLPYP EAIFELPFFF HNPKPFFTLA KELYPGNYKP NVTHYFLRLL HDKGLLLRLY TQNIDGLERV SGIPASKLVE AHGTFASATC TVCQRPFPGE DIRADVMADR VPRCPVCTGV VKPDIVFFGE PLPQRFLLHV VDFPMADLLL ILGTSLEVEP FASLTEAVRS SVPRLLINRD LVGPLAWHPR SRDVAQLGDV VHGVESLVEL LGWTEEMRDL VQRETGKLDG PDK |
SIRT3 is a member of a family of proteins called Sirtuin. Proteins of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The roles of human Sirtuins are numerous and are important in aging prosseses, stress resistance and metabolic regulation. SIRT3 shows NAD+-dependent deacetylase activity in the mitochondria. Over-expression of SIRT3 causes increased levels of the mitochondrial uncoupling protein 1. Also, in certain breast cancers the levels of SIRT3 protein are found to be extremely high.
SIRT3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 303 amino acids (118-399a.a.) and having a molecular mass of 33.5kDa.SIRT3 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Code: | Q9NTG7 |
| NCBI GenInfo Identifier: | 38258651 |
| NCBI Gene ID: | 23410 |
| NCBI Accession: | Q9NTG7.2 |
| UniProt Secondary Accession: | Q9NTG7,Q9Y6E8, B7Z5U6, |
| UniProt Related Accession: | Q9NTG7 |
| Molecular Weight: | 399 |
| NCBI Full Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
| NCBI Synonym Full Names: | sirtuin 3 |
| NCBI Official Symbol: | SIRT3�� |
| NCBI Official Synonym Symbols: | SIR2L3�� |
| NCBI Protein Information: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial; sir2-like 3; sirtuin type 3; SIR2-like protein 3; regulatory protein SIR2 homolog 3; NAD-dependent deacetylase sirtuin-3, mitochondrial; silent mating type information regulation 2, S.cerevisiae, homolog 3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase |
| UniProt Protein Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
| UniProt Synonym Protein Names: | Regulatory protein SIR2 homolog 3; SIR2-like protein 3 |
| Protein Family: | NAD-dependent protein deacetylase sirtuin |
| UniProt Gene Name: | SIRT3�� |
| UniProt Entry Name: | SIR3_HUMAN |
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