Human SGCB Recombinant Protein (RPPB4659)
- SKU:
- RPPB4659
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16585
Description
| Product Name: | Human SGCB Recombinant Protein |
| Product Code: | RPPB4659 |
| Size: | 20µg |
| Species: | Human |
| Target: | SGCB |
| Synonyms: | Beta-sarcoglycan, Beta-SG, 43 kDa dystrophin-associatedglycoprotein, 43DAG, A3b, LGMD2E, Sarcoglycan, Beta (43kDaDystrophin-Associated Glycoprotein), Limb Girdle Muscular Dystrophy 2E(Non-Linked Families), SGC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SGCB protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer(pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSWAVIRIGPNGCDSMEFH ESGLLRFKQV SDMGVIHPLY KSTVGGRRNE NLVITGNNQP IVFQQGTTKL SVENNKTSITSDIGMQFFDP RTQNILFSTD YETHEFHLPS GVKSLNVQKA STERITSNAT SDLNIKVDGR AIVRGNEGVFIMGKTIEFHM GGNMELKAEN SIILNGSVMV STTRLPSSSS GDQLGSGDWV RYKLCMCADG TLFKVQVTSQNMGCQISDNP CGNTH |
SarcoglycanBeta, also known as SGCB, is a part of the sarcoglycan family. SGCB belongs to thesarcoglycan complex which is a subcomplex of the dystrophin-glycoproteincomplex that connects between the F-actin cytoskeleton and the extracellularmatrix.
SGCB Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 255 amino acids (87-318 a.a) andhaving a molecular mass of 27.8kDa.SGCB is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SGCB: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCB are the cause of limb-girdle muscular dystrophy type 2E (LGMD2E). LGMD2E is an autosomal recessive disorder. Belongs to the sarcoglycan beta/delta/gamma/zeta family. |
| UniProt Protein Details: | Protein type:Dystrophin complex; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q12 Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; integral to plasma membrane; cytoplasm; sarcoglycan complex; sarcolemma Biological Process: muscle development; cardiac muscle cell development; muscle fiber development Disease: Muscular Dystrophy, Limb-girdle, Type 2e |
| NCBI Summary: | This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008] |
| UniProt Code: | Q16585 |
| NCBI GenInfo Identifier: | 13431857 |
| NCBI Gene ID: | 6443 |
| NCBI Accession: | Q16585.1 |
| UniProt Secondary Accession: | Q16585,O00661, B7Z635, |
| UniProt Related Accession: | Q16585 |
| Molecular Weight: | 318 |
| NCBI Full Name: | Beta-sarcoglycan |
| NCBI Synonym Full Names: | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) |
| NCBI Official Symbol: | SGCB�� |
| NCBI Official Synonym Symbols: | A3b; SGC; LGMD2E�� |
| NCBI Protein Information: | beta-sarcoglycan; 43DAG; beta-SG; 43 kDa dystrophin-associated glycoprotein; limb girdle muscular dystrophy 2E (non-linked families); beta-sarcoglycan(43kD dystrophin-associated glycoprotein) |
| UniProt Protein Name: | Beta-sarcoglycan |
| UniProt Synonym Protein Names: | 43 kDa dystrophin-associated glycoprotein; 43DAG; A3b |
| Protein Family: | Beta-sarcoglycan |
| UniProt Gene Name: | SGCB�� |
| UniProt Entry Name: | SGCB_HUMAN |
