Human SFTPD Recombinant Protein (RPPB4665)
- SKU:
- RPPB4665
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P35247
Description
| Product Name: | Human SFTPD Recombinant Protein |
| Product Code: | RPPB4665 |
| Size: | 10µg |
| Species: | Human |
| Target: | SFTPD |
| Synonyms: | Surfactant Protein D, Lung Surfactant Protein D, Collectin-7, COLEC7, SFTP4, PSP-D, SP-D, Surfactant-Associated Protein, Pulmonary 4, Surfactant, Pulmonary-Associated Protein D, Pulmonary Surfactant-Associated Protein D, Pulmonary Surfactant Apoprotein, PSPD. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SFTPD protein solution (0.25mg/ml) contains 10% glycerol & Phosphate Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPEMKTYSH RTMPSACTLV MCSSVESGLP GRDGRDGREG PRGEKGDPGL PGAAGQAGMP GQAGPVGPKG DNGSVGEPGP KGDTGPSGPP GPPGVPGPAG REGPLGKQGN IGPQGKPGPK GEAGPKGEVG APGMQGSAGA RGLAGPKGER GVPGERGVPG NTGAAGSAGA GPQGSPGARGPPGLKGDKG IPGDKGAKGE SGLPDVASLR QQVEALQGQV QHLQAAFSQY KKVELFPNGQ SVGEKIFKTA GFVKPFTEAQ LLCTQAGGQL ASPRSAAENA ALQQLVVAKN EAAFLSMTDS KTEGKFTYPT GESLVYSNWA PGEPNDDGGS EDCVEIFTNG KWNDRACGEK RLVVCEFHHH�HHH |
Surfactant pulmonary-associated protein D (SFTPD) belongs to the collectin family of C-type lectins, which is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. SFTPD has humoral molecules of the innate immune system, and is deemed a functional candidate in chronic periodontitis. Moreover, SFTPD is involved in the development of acute and chronic inflammation of the lung. A number of human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. SFTPD contributes to the lungs defense against inhaled microorganisms, organic antigens and toxins. SFTPD interacts with complexes such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. In addition, SFTPD participates in the extracellular reorganization or turnover of pulmonary surfactant. SFTPD binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
SFTPD produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 363 amino acids (22-375 a.a.) and having a molecular mass of 36.5kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).SFTPD is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SFTPD: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. Belongs to the SFTPD family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 10q22.2-q23.1 Cellular Component: proteinaceous extracellular matrix; extracellular space; collagen; lysosome; endocytic vesicle; extracellular region Molecular Function:protein binding; carbohydrate binding Biological Process: receptor-mediated endocytosis; negative regulation of T cell proliferation; positive regulation of phagocytosis; defense response to bacterium; negative regulation of interleukin-2 biosynthetic process; innate immune response; respiratory gaseous exchange; surfactant homeostasis; macrophage chemotaxis; alveolus development; regulation of cytokine production |
| NCBI Summary: | The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P35247 |
| NCBI GenInfo Identifier: | 317373510 |
| NCBI Gene ID: | 6441 |
| NCBI Accession: | P35247.3 |
| UniProt Secondary Accession: | P35247,Q5T0M3, Q6FH08, Q86YK9, Q8TCD8, Q9UCJ2, Q9UCJ3 |
| UniProt Related Accession: | P35247 |
| Molecular Weight: | 37,728 Da |
| NCBI Full Name: | Pulmonary surfactant-associated protein D |
| NCBI Synonym Full Names: | surfactant protein D |
| NCBI Official Symbol: | SFTPD�� |
| NCBI Official Synonym Symbols: | SP-D; PSP-D; SFTP4; COLEC7�� |
| NCBI Protein Information: | pulmonary surfactant-associated protein D |
| UniProt Protein Name: | Pulmonary surfactant-associated protein D |
| UniProt Synonym Protein Names: | Collectin-7; Lung surfactant protein D |
| UniProt Gene Name: | SFTPD�� |
| UniProt Entry Name: | SFTPD_HUMAN |
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