Human SDC2 Recombinant Protein (RPPB4601)
- SKU:
- RPPB4601
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P34741
Description
| Product Name: | Human SDC2 Recombinant Protein |
| Product Code: | RPPB4601 |
| Size: | 5µg |
| Species: | Human |
| Target: | SDC2 |
| Synonyms: | Syndecan 2, Heparan Sulfate Proteoglycan 1 Cell Surface-Associated, Heparan Sulfate Proteoglycan Core Protein, Syndecan Proteoglycan 2, Fibroglycan, HSPG1, SYND2, HSPG, Cell Surface-Associated Heparan Sulfate Proteoglycan 1, CD362 Antigen, Syndecan-2, CD362, SDC2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | SDC2 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPESRAELT SDKDMYLDNS SIEEASGVYP IDDDDYASAS GSGADEDVES PELTTSRPLP KILLTSAAPK VETTTLNIQN KIPAQTKSPE ETDKEKVHLS DSERKMDPAE EDTNVYTEKH SDSLFKRTEH HHHHH |
Syndecan 2 (SDC2) is a conserved family of heparan- and chondroitin-sulfate carrying transmembrane protein. Syndecan 2 is a cell membrane proteoglycan which modulates the activity and dynamics of some growth factor receptors and integrins. SDC2 is expressed in HSCs (hepatic stellate cells), a key cell type involved in matrix deposition in liver fibrotic disorders. SDC2 is implicated in the formation of specialized membrane domains and serves as a direct link between the extracellular environment and the organization of the cortical cytoplasm.�
SDC2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 135 amino acids (19-144a.a.) and having a molecular mass of 15kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). SDC2 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | syndecan-2: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Preferentially expressed in cells of mesenchymal origin. Is tyrosine phosphorylated and forms a complex with EphB2 in mouse brain. Plays a role in mediating adhesion and proliferation of colon carcinoma cells. |
| UniProt Protein Details: | Protein type:Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 8q22-q23 Cellular Component: lysosomal lumen; cell soma; Golgi lumen; integral to membrane; plasma membrane; synapse Molecular Function:protein binding; PDZ domain binding Biological Process: axon guidance; phototransduction, visible light; extracellular matrix organization and biogenesis; wound healing; glycosaminoglycan metabolic process; dendrite morphogenesis; regulation of dendrite morphogenesis; pathogenesis; response to caffeine; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; carbohydrate metabolic process; ephrin receptor signaling pathway; response to hypoxia; retinoid metabolic process |
| NCBI Summary: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P34741 |
| NCBI GenInfo Identifier: | 158962336 |
| NCBI Gene ID: | 6383 |
| NCBI Accession: | P34741.2 |
| UniProt Related Accession: | P34741 |
| Molecular Weight: | |
| NCBI Full Name: | Syndecan-2 |
| NCBI Synonym Full Names: | syndecan 2 |
| NCBI Official Symbol: | SDC2�� |
| NCBI Official Synonym Symbols: | HSPG; CD362; HSPG1; SYND2�� |
| NCBI Protein Information: | syndecan-2 |
| UniProt Protein Name: | Syndecan-2 |
| UniProt Synonym Protein Names: | Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD_antigen: CD362 |
| Protein Family: | Syndecan |
| UniProt Gene Name: | SDC2�� |
| UniProt Entry Name: | SDC2_HUMAN |
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