Human SCGB1A1 Recombinant Protein (RPPB0898)
- SKU:
- RPPB0898
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P11684
- Research Area:
- Cytokines
Description
| Product Name: | Human SCGB1A1 Recombinant Protein |
| Product Code: | RPPB0898 |
| Size: | 10µg |
| Species: | Human |
| Target: | SCGB1A1 |
| Synonyms: | Uteroglobin, Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, Secretoglobin family 1A member 1, Urinary protein 1, UP-1, UP1, Urine protein 1, SCGB1A1, CCSP, UGB, CC16. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Filtered (0.4 �m) and lyophilized from 0.5 mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4. |
| Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. SCGB1A1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASEICPSFQRVI ETLLMDTPSS YEAAMELFSP DQDMREAGAQ LKKLVDTLPQ KPRESIIKLM EKIAQSSLCN |
Uteroglobin (SCGB1A1) which belongs to the Secretoglobin (SCGBs) superfamily, is a multifunctional protein that exerts anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. SCGB1A1 is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. On top of sequestering pro-inflammatory mediators and carcinogens, Uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. SCGB1A1 gene defects are associated with a susceptibility to asthma.
Uteroglobin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 80 amino acids and including a 10 a.a N-terminal His tag.�The total molecular mass is 9.2kDa (calculated).
| UniProt Protein Function: | SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family. |
| UniProt Protein Details: | Protein type:Secreted; Cell cycle regulation; Secreted, signal peptide; Inhibitor Chromosomal Location of Human Ortholog: 11q12.3 Cellular Component: extracellular space; rough endoplasmic reticulum; nuclear envelope; secretory granule Molecular Function:protein binding; phospholipase A2 inhibitor activity Biological Process: response to drug; negative regulation of interleukin-4 production; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; negative regulation of transcription from RNA polymerase II promoter; signal transduction; regulation of mRNA stability; response to xenobiotic stimulus; response to silicon dioxide; negative regulation of interleukin-13 production; negative regulation of T cell proliferation; response to ozone; negative regulation of interferon-gamma production; response to cytokine stimulus; negative regulation of catalytic activity; regulation of inflammatory response; negative regulation of interleukin-5 production; embryo implantation Disease: Asthma, Susceptibility To |
| NCBI Summary: | This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010] |
| UniProt Code: | P11684 |
| NCBI GenInfo Identifier: | 112672 |
| NCBI Gene ID: | 7356 |
| NCBI Accession: | P11684.1 |
| UniProt Related Accession: | P11684 |
| Molecular Weight: | 16kDa |
| NCBI Full Name: | Uteroglobin |
| NCBI Synonym Full Names: | secretoglobin family 1A member 1 |
| NCBI Official Symbol: | SCGB1A1�� |
| NCBI Official Synonym Symbols: | UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP�� |
| NCBI Protein Information: | uteroglobin |
| UniProt Protein Name: | Uteroglobin |
| UniProt Synonym Protein Names: | Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; Secretoglobin family 1A member 1; Urinary protein 1; UP-1; UP1; Urine protein 1 |
| Protein Family: | Uteroglobin |
| UniProt Gene Name: | SCGB1A1�� |
| UniProt Entry Name: | UTER_HUMAN |
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