Human SAA1 Recombinant Protein (RPPB0942)
- SKU:
- RPPB0942
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P0DJI8
- Research Area:
- Cytokines
Description
| Product Name: | Human SAA1 Recombinant Protein |
| Product Code: | RPPB0942 |
| Size: | 50µg |
| Species: | Human |
| Target: | SAA1 |
| Synonyms: | Serum amyloid A protein, SAA, Amyloid protein A, Amyloid fibril protein AA, SAA1, SAA2, PIG4, TP53I4, MGC111216. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | SAA1 was lyophilized from a 0.2�m filtered concentrated solution in 20mM Tris-HCl, pH 9.0 and 150mM NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized SAA1 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized SAA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution SAA1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | RSFFSFLGEA FDGARDMWRA YSDMREANYI GSDKYFHARG NYDAAKRGPG GVWAAEAISD ARENIQRFFG HGAEDSLADQ AANEWGRSGK DPNHFRPAGL PEKY |
| Biological Activity: | The biological activity determined by a chemoattract bioassay using human monocytes is in a concentration range of 10-100 ng/ml. |
SAA1 protein is an acute phase apolipoprotein reactant which is produced mostly by hepatocytes and under regulation of inflammatory cytokines. SAA1 (Serum amyloid A1) protein is produced mainly in the liver and circulates in low levels in the blood. The SAA1 seems to have a role in the immune system. SAA1 protein levels increase in the blood and other tissues under conditions of inflammation. SAA1 may facilitate the repair of injured tissues; it also acts as an antibacterial agent, and signals the migration of germ-fighting cells to sites of infection. SAA1 also functions as an apolipoprotein of the HDL complex.Elevated levels of SAA1 ultimately affect secondary amyloidosis, extracellular amassing of amyloid fibrils, resulting from a circulating precursor, in a variety of tissues and organs. The most widespread type of amyloidosis appears secondary to chronic inflammatory disease, mainly rheumatoid arthritis. The SAA1 cleavage product a designated amyloid protein A is deposited systemically as amyloid in vital organs such as the liver, spleen, and kidneys in chronic inflammatory diseases patients. These deposits are extremely insoluble and resistant to proteolysis; they disrupt tissue structure and compromise performance.
SAA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 104 amino acids and having a molecular mass of 11.7kDa. The SAA1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: extracellular region Molecular Function:heparin binding; G-protein-coupled receptor binding Biological Process: positive regulation of interleukin-1 secretion; receptor-mediated endocytosis; platelet activation; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; positive regulation of cell adhesion; regulation of protein secretion; negative regulation of inflammatory response; acute-phase response; innate immune response; lymphocyte chemotaxis; macrophage chemotaxis; positive regulation of cytokine secretion |
| NCBI Summary: | This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012] |
| UniProt Code: | P0DJI8 |
| NCBI GenInfo Identifier: | 395406826 |
| NCBI Gene ID: | 6288 |
| NCBI Accession: | P0DJI8.1 |
| UniProt Secondary Accession: | P0DJI8,P02735, P02736, P02737, Q16730, Q16834, Q16835 Q16879, Q3KRB3, Q6FG67, Q96QN0, Q9UCK9, |
| UniProt Related Accession: | P0DJI8 |
| Molecular Weight: | 122 |
| NCBI Full Name: | Serum amyloid A-1 protein |
| NCBI Synonym Full Names: | serum amyloid A1 |
| NCBI Official Symbol: | SAA1�� |
| NCBI Official Synonym Symbols: | SAA; PIG4; SAA2; TP53I4�� |
| NCBI Protein Information: | serum amyloid A-1 protein; serum amyloid A protein; tumor protein p53 inducible protein 4 |
| UniProt Protein Name: | Serum amyloid A-1 protein |
| UniProt Synonym Protein Names: | Amyloid fibril protein AA |
| UniProt Gene Name: | SAA1�� |
| UniProt Entry Name: | SAA1_HUMAN |
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