Human RNMT Recombinant Protein (RPPB2253)
- SKU:
- RPPB2253
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43148
- Research Area:
- Enzymes
Frequently bought together:
Description
| Product Name: | Human RNMT Recombinant Protein |
| Product Code: | RPPB2253 |
| Size: | 10µg |
| Species: | Human |
| Target: | RNMT |
| Synonyms: | mRNA cap guanine-N7 methyltransferase, RG7MT1, mRNA (guanine-N(7)-)-methyltransferase, mRNA cap methyltransferase, hCMT1, hMet, hcm1p, RNMT, KIAA0398, MET, RG7MT1, hCMT1c, DKFZp686H1252. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | RNMT solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) 2mM DTT, 20% glycerol and 100mM NaCl. |
| Stability: | RNMT Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MANSAKAEEY EKMSLEQAKA SVNSETESSF NINENTTASG TGLSEKTSVC RQVDIARKRK EFEDDLVKES SSCGKDTPSK KRKLDPEIVP EEKDCGDAEG NSKKRKRETE DVPKDKSSTG DGTQNKRKIA LEDVPEKQKN LEEGHSSTVA AHYNELQEVG LEKRSQSRIF YLRNFNNWMK SVLIGEFLEK VRQKKKRDIT VLDLGCGKGG DLLKWKKGRI NKLVCTDIAD VSVKQCQQRY EDMKNRRDSE YIFSAEFITA DSSKELLIDK FRDPQMCFDI CSCQFVCHYS FESYEQADMM LRNACERLSP GGYFIGTTPN SFELIRRLEA SETESFGNEI YTVKFQKKGD YPLFGCKYDF NLEGVVDVPE FLVYFPLLNE MAKKYNMKLV YKKTFLEFYE EKIKNNENKM LLKRMQALEP YPANESSKLV SEKVDDYEHA AKYMKNSQVR LPLGTLSKSE WEATSIYLVF AFEKQQ |
RNMT is a widely expressed nuclear protein which is a member of the mRNA cap methyltransferase family. Cap-dependent mRNA translation requires the methylation of the mRNA guanosine cap by RNMT. RNMT catalyzes the transfer of a methyl group from AdoMet (S-adenosylmethionine) to the GpppN end of the growing mRNA at the N-7 position, thus producing AdoHyc (S-adenosylhomocysteine) and m7GpppN terminated RNA.
RNMT produced in E.Coli is a single, non-glycosylated polypeptide chain containing 496 amino acids (1-476 a.a.) and having a molecular mass of 57kDa.RNMT is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O43148 |
| NCBI GenInfo Identifier: | 74735378 |
| NCBI Gene ID: | 8731 |
| NCBI Accession: | O43148.1 |
| UniProt Secondary Accession: | O43148,O94996, Q9UIJ9, B0YJ90, D3DUJ5 |
| UniProt Related Accession: | O43148 |
| Molecular Weight: | 476 |
| NCBI Full Name: | mRNA cap guanine-N7 methyltransferase |
| NCBI Synonym Full Names: | RNA (guanine-7-) methyltransferase |
| NCBI Official Symbol: | RNMT�� |
| NCBI Official Synonym Symbols: | MET; RG7MT1; hCMT1c�� |
| NCBI Protein Information: | mRNA cap guanine-N7 methyltransferase; hMet; hCMT1; hcm1p; mRNA cap methyltransferase; mRNA (guanine-7-)methyltransferase; mRNA (guanine-N(7)-)-methyltransferase |
| UniProt Protein Name: | mRNA cap guanine-N7 methyltransferase |
| UniProt Synonym Protein Names: | RG7MT1; mRNA (guanine-N(7)-)-methyltransferase; mRNA cap methyltransferase; hCMT1; hMet; hcm1p |
| Protein Family: | |
| UniProt Gene Name: | RNMT�� |
| UniProt Entry Name: | MCES_HUMAN |
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