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Human RHOQ Recombinant Protein (RPPB4463)

SKU:
RPPB4463
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P17081
€469
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Description

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Product Name:Human RHOQ Recombinant Protein
Product Code:RPPB4463
Size:10µg
Species:Human
Target:RHOQ
Synonyms:ARHQ, RASL7A, TC10, TC10A, Rho-related GTP-binding protein RhoQ, Ras-like protein TC10, Ras-like protein family member 7A, RHOQ.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RHOQ protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAHGPGA LMLKCVVVGD GAVGKTCLLM SYANDAFPEE YVPTVFDHYA VSVTVGGKQY LLGLYDTAGQ EDYDRLRPLS YPMTDVFLIC FSVVNPASFQ NVKEEWVPEL KEYAPNVPFL LIGTQIDLRD DPKTLARLND MKEKPICVEQ GQKLAKEIGA CCYVECSALT QKGLKTVFDE AIIAILTPKK HTVKKRIGSR CINCC

RHOQ (rho-related GTP-binding protein RhoQ) is a small signaling G protein which cycles between an active GTP-bound and an inactive GDP-bound state. In the active state it binds to a diversity of effector proteins to regulate cellular responses. Ras-like protein belongs to the Rac subfamily of the Rho family of GTPases. RHOQ is involved in epithelial cell polarization processes. In addition, RHOQ plays a role in CFTR trafficking to the plasma membrane. RHOQ causes the formation of thin, actin-rich surface projections called filopodia.

RHOQ Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids (1-202 a.a) and having a molecular mass of 24.7kDa. RHOQ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RHOQ: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. Belongs to the small GTPase superfamily. Rho family.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rho

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: actin filament; cytosol; plasma membrane

Molecular Function:GBD domain binding; GTPase activity; profilin binding

Biological Process: cellular response to insulin stimulus; cortical actin cytoskeleton organization and biogenesis; GTP metabolic process; insulin receptor signaling pathway; positive regulation of filopodium formation; positive regulation of glucose import; positive regulation of transcription from RNA polymerase II promoter; regulation of actin cytoskeleton organization and biogenesis; regulation of small GTPase mediated signal transduction

NCBI Summary:This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]
UniProt Code:P17081
NCBI GenInfo Identifier:33440525
NCBI Gene ID:23433
NCBI Accession:BC056154
UniProt Secondary Accession:P17081,Q0VGN1, Q52LS8, Q53SJ1, Q6NS39, Q6P146, Q7Z480 D6W5A6,
UniProt Related Accession:P17081
Molecular Weight:22,659 Da
NCBI Full Name:Homo sapiens ras homolog gene family, member Q, mRNA
NCBI Synonym Full Names:ras homolog family member Q
NCBI Official Symbol:RHOQ��
NCBI Official Synonym Symbols:ARHQ; TC10; TC10A; RASL7A; HEL-S-42��
NCBI Protein Information:rho-related GTP-binding protein RhoQ
UniProt Protein Name:Rho-related GTP-binding protein RhoQ
UniProt Synonym Protein Names:Ras-like protein TC10; Ras-like protein family member 7A
Protein Family:Rho-related GTP-binding protein
UniProt Gene Name:RHOQ��
UniProt Entry Name:RHOQ_HUMAN

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