Human RAMP1 Recombinant Protein (RPPB4395)
- SKU:
- RPPB4395
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O60894
Description
| Product Name: | Human RAMP1 Recombinant Protein |
| Product Code: | RPPB4395 |
| Size: | 10µg |
| Species: | Human |
| Target: | RAMP1 |
| Synonyms: | Receptor (G Protein-Coupled) Activity Modifying Protein 1, Receptor (Calcitonin) Activity Modifying Protein 1, Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 1, CRLR Activity-Modifying Protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The RAMP1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSCQEANYG ALLRELCLTQ FQVDMEAVGE TLWCDWGRTI RSYRELADCT WHMAEKLGCF WPNAEVDRFF LAVHGRYFRS CPISGRAVRD PPGS |
RAMP belongs to the type I transmembrane family of proteins called RAMP (receptor/calcitonin activity modifying proteins) which include an extracellular N terminus and a cytoplasmic C terminus. RAMPs are essential for CRLR transport to the plasma membrane. CRLR (calcitonin-receptor-like receptor) has seven transmembrane domains. Depending on which members of the RAMP family are expressed CRLR receptor functions as either an adrenomedullin receptor or a calcitonin-gene-related peptide (CGRP) receptor. In the presence of RAMP1, CRLR functions as a CGRP receptor. The RAMP1 protein takes part in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
RAMP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 114 amino acids (27-117) and having a molecular mass of 12.9 kDa. RAMP1 is fused to a 23 amino acid His-tag at N-terminus.
| UniProt Protein Function: | RAMP1: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Belongs to the RAMP family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 2q36-q37.1 Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane; receptor complex Molecular Function:protein binding; calcitonin receptor binding; coreceptor activity; receptor activity; protein transporter activity; calcitonin receptor activity Biological Process: intracellular protein transport; G-protein coupled receptor protein signaling pathway; protein transport; positive regulation of protein amino acid glycosylation; receptor internalization; calcium ion transport; positive regulation of cAMP biosynthetic process; angiogenesis; regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60894 |
| NCBI GenInfo Identifier: | 11134419 |
| NCBI Gene ID: | 10267 |
| NCBI Accession: | O60894.1 |
| UniProt Secondary Accession: | O60894,Q6FGS5, |
| UniProt Related Accession: | O60894 |
| Molecular Weight: | 148 |
| NCBI Full Name: | Receptor activity-modifying protein 1 |
| NCBI Synonym Full Names: | receptor (G protein-coupled) activity modifying protein 1 |
| NCBI Official Symbol: | RAMP1�� |
| NCBI Protein Information: | receptor activity-modifying protein 1; CRLR activity-modifying protein 1; receptor activity modifying protein 1; receptor (calcitonin) activity modifying protein 1; calcitonin receptor-like receptor activity modifying protein 1; calcitonin-receptor-like receptor activity-modifying protein 1 |
| UniProt Protein Name: | Receptor activity-modifying protein 1 |
| UniProt Synonym Protein Names: | Calcitonin-receptor-like receptor activity-modifying protein 1; CRLR activity-modifying protein 1 |
| Protein Family: | Receptor activity-modifying protein |
| UniProt Gene Name: | RAMP1�� |
| UniProt Entry Name: | RAMP1_HUMAN |
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