Human RAC3 Recombinant Protein (RPPB4381)
- SKU:
- RPPB4381
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P60763
Description
| Product Name: | Human RAC3 Recombinant Protein |
| Product Code: | RPPB4381 |
| Size: | 20µg |
| Species: | Human |
| Target: | RAC3 |
| Synonyms: | Ras-related C3 substrate 3, p21-Rac3, RAC3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RAC3 solution (0.5mg/ml)�contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 2mM DTT, 200mM NaCl, 0.1mM PMSF and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKPGKKC |
RAC3 belongs to the Rac subfamily of the Rho small G proteins. RAC3 is a small (approximately 21kDa) monomeric GTP-binding protein, which is an important component of intracellular signaling pathway, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
RAC3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 189 amino acids (1-189 a.a.) and having a total molecular mass of 21kDa.RAC3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAC3: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. Highest levels in brain, also detected in heart, placenta and pancreas. Belongs to the small GTPase superfamily. Rho family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; G protein; G protein, monomeric; G protein, monomeric, Rho Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: filamentous actin; neuron projection; growth cone; cell soma; perinuclear region of cytoplasm; lamellipodium; plasma membrane; endomembrane system; cytosol Molecular Function:GTPase activity; protein binding; GTP binding; calcium-dependent protein binding Biological Process: regulation of small GTPase mediated signal transduction; metabolic process; small GTPase mediated signal transduction; positive regulation of cell adhesion mediated by integrin; cell projection biogenesis; actin cytoskeleton organization and biogenesis; neuromuscular process controlling balance; neurite development |
| NCBI Summary: | The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P60763 |
| NCBI GenInfo Identifier: | 46397673 |
| NCBI Gene ID: | 5881 |
| NCBI Accession: | P60763.1 |
| UniProt Related Accession: | P60763 |
| Molecular Weight: | |
| NCBI Full Name: | Ras-related C3 botulinum toxin substrate 3 |
| NCBI Synonym Full Names: | Rac family small GTPase 3 |
| NCBI Official Symbol: | RAC3�� |
| NCBI Protein Information: | ras-related C3 botulinum toxin substrate 3 |
| UniProt Protein Name: | Ras-related C3 botulinum toxin substrate 3 |
| UniProt Synonym Protein Names: | p21-Rac3 |
| Protein Family: | Rac-like GTP-binding protein |
| UniProt Gene Name: | RAC3�� |
| UniProt Entry Name: | RAC3_HUMAN |
