Human RAB11A Recombinant Protein (RPPB4344)
- SKU:
- RPPB4344
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P62491
Description
| Product Name: | Human RAB11A Recombinant Protein |
| Product Code: | RPPB4344 |
| Size: | 25µg |
| Species: | Human |
| Target: | RAB11A |
| Synonyms: | RAB11, YL8, Ras-related protein Rab-11A, RAB11A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | RAB11A Human solution containing 20mM Tris-HCl pH-8, 1mM DTT, 1mM EDTA & 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGTR DDEYDYLFKV VLIGDSGVGK SNLLSRFTRN EFNLESKSTI GVEFATRSIQ VDGKTIKAQI WDTAGQERYR AITSAYYRGA VGALLVYDIA KHLTYENVER WLKELRDHAD SNIVIMLVGN KSDLRHLRAV PTDEARAFAE KNGLSFIETS ALDSTNVEAA FQTILTEIYR IVSQKQMSDR RENDMSPSNN VVPIHVPPTT ENKPKVQCC |
RAB11A is part of the small GTPase superfamily, Rab family. RAB11A is related with both constitutive and regulated secretory pathways, and takes part in protein transport. RAB11A is a well-known marker for protein trafficking, sorting, and recycling in the endosomal pathway. RAB11A is a main regulator of membrane delivery during cytokinesis.
RAB11A Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 249 amino acids (1-213a.a.) and having a molecular mass of 28.1 kDa. RAB11A protein is fused to a 36 amino acid His tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | RAB11A: Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3. Interacts with EXOC6 in a GTP- dependent manner. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SPE39//C14orf133. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein; G protein, monomeric, Rab; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: Golgi apparatus; spindle pole; protein complex; cytoplasmic vesicle membrane; mitochondrion; recycling endosome membrane; phagocytic vesicle; trans-Golgi network; cytosol; kinetochore microtubule; multivesicular body; recycling endosome; phagocytic vesicle membrane; transport vesicle; perinuclear region of cytoplasm; axon; plasma membrane; cytoplasmic vesicle; vesicle; cleavage furrow Molecular Function:GTPase activity; protein binding; GDP binding; syntaxin binding; GTP binding; microtubule binding; myosin V binding Biological Process: regulation of long-term neuronal synaptic plasticity; establishment of vesicle localization; exocytosis; metabolic process; organelle organization and biogenesis; positive regulation of axon extension; water transport; cytokinesis; melanosome transport; mitotic metaphase plate congression; vesicle-mediated transport; regulation of protein transport; intracellular protein transport; astral microtubule organization and biogenesis; renal water homeostasis; plasma membrane to endosome transport; Rab protein signal transduction; transmembrane transport; neurite development |
| NCBI Summary: | The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | P62491 |
| NCBI GenInfo Identifier: | 50402542 |
| NCBI Gene ID: | 8766 |
| NCBI Accession: | P62491.3 |
| UniProt Secondary Accession: | P62491,P24410, Q5TZN9, Q9JLX1, B2R4B6, B4DT13, |
| UniProt Related Accession: | P62491 |
| Molecular Weight: | 17,659 Da |
| NCBI Full Name: | Ras-related protein Rab-11A |
| NCBI Synonym Full Names: | RAB11A, member RAS oncogene family |
| NCBI Official Symbol: | RAB11A�� |
| NCBI Official Synonym Symbols: | YL8�� |
| NCBI Protein Information: | ras-related protein Rab-11A; rab-11; RAB 11A, member oncogene family |
| UniProt Protein Name: | Ras-related protein Rab-11A |
| UniProt Synonym Protein Names: | YL8 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB11A�� |
| UniProt Entry Name: | RB11A_HUMAN |
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