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Human RAB10 Recombinant Protein (RPPB4343)

SKU:
RPPB4343
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P61026
€309
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Description

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Product Name:Human RAB10 Recombinant Protein
Product Code:RPPB4343
Size:10µg
Species:Human
Target:RAB10
Synonyms:Ras-related GTP-binding protein RAB10, Ras-related protein Rab-10, RAB10, Rab10, member RAS oncogene family.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RAB10 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAKKTYDLLF KLLLIGDSGV GKTCVLFRFS DDAFNTTFIS TIGIDFKIKT VELQGKKIKL QIWDTAGQER FHTITTSYYR GAMGIMLVYD ITNGKSFENI SKWLRNIDEH ANEDVERMLL GNKCDMDDKR VVPKGKGEQI AREHGIRFFE TSAKANINIE KAFLTLAEDI LRKTPVKEPN SENVDISSGG GVTGWKSKCC

RAB10, Member RAS Oncogene Family (RAB10) belongs to the Ras superfamily of small GTP-binding proteins. RAB10 is a key regulator of endocytic recycling, particularly in the basolateral recycling pathways of polarized epithelial cells. It is required for the recruitment of CNT-1 to endosomal membranes in the intestinal epithelium.

RAB10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-200) and having a molecular mass of 24.7 kDa. RAB10 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RAB10: a protein of the GTPase superfamily, Rab family. May be involved in vesicular trafficking and neurotransmitter release. Localized to the inner face of the cell membrane by a lipid-anchor.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: Golgi apparatus; phagocytic vesicle membrane; endoplasmic reticulum membrane; recycling endosome; cytoplasmic vesicle membrane; focal adhesion; recycling endosome membrane; exocyst; plasma membrane; endosome membrane; trans-Golgi network; endosome

Molecular Function:GTPase activity; GDP binding; GTP binding; myosin V binding

Biological Process: metabolic process; establishment of neuroblast polarity; protein secretion; endosome transport; regulation of exocytosis; vesicle-mediated transport; polarized epithelial cell differentiation; intracellular protein transport; Golgi to plasma membrane transport; antigen processing and presentation; cellular response to insulin stimulus; axonogenesis; Golgi to plasma membrane protein transport; Rab protein signal transduction; vesicle docking during exocytosis

NCBI Summary:RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]
UniProt Code:P61026
NCBI GenInfo Identifier:46577638
NCBI Gene ID:10890
NCBI Accession:P61026.1
UniProt Related Accession:P61026
Molecular Weight:22.5kDa
NCBI Full Name:Ras-related protein Rab-10
NCBI Synonym Full Names:RAB10, member RAS oncogene family
NCBI Official Symbol:RAB10��
NCBI Protein Information:ras-related protein Rab-10
UniProt Protein Name:Ras-related protein Rab-10
Protein Family:Ras-related protein
UniProt Gene Name:RAB10��
UniProt Entry Name:RAB10_HUMAN

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