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Human PVALB Recombinant Protein (RPPB4339)

SKU:
RPPB4339
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P20472
€309
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Description

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Product Name:Human PVALB Recombinant Protein
Product Code:RPPB4339
Size:25µg
Species:Human
Target:PVALB
Synonyms:Parvalbumin alpha, PVALB, D22S749, MGC116759.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PVALB solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 50mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSMTDL LNAEDIKKAV GAFSATDSFD HKKFFQMVGLKKKSADDVKK VFHMLDKDKS GFIEEDELGF ILKGFSPDAR DLSAKETKML MAAGDKDGDG KIGVDEFSTL VAES

Parvalbumin alpha (PVALB) is a member of a larger group of EF hand proteins. PVALB is a high affinity calcium ion-binding protein which is structurally and functionally similar to calmodulin and troponin C. Parvalbumin is expressed in a specific population of GABAergic interneurones which are believed to have a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus.

PVALB Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids (1-110 a.a.) and having a molecular mass of 14.6kDa. The PVALB is purified by proprietary chromatographic techniques.

UniProt Protein Function:PVA: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Belongs to the parvalbumin family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: protein complex; cell soma; axon; cytoplasm; nucleus

Molecular Function:protein homodimerization activity; protein heterodimerization activity; calcium ion binding

Biological Process: cytosolic calcium ion homeostasis

NCBI Summary:The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. [provided by RefSeq, Jul 2008]
UniProt Code:P20472
NCBI GenInfo Identifier:131100
NCBI Gene ID:5816
NCBI Accession:P20472.2
UniProt Secondary Accession:P20472,P78378, Q4VB78, Q5R3Q9, B2R4H7,
UniProt Related Accession:P20472
Molecular Weight:110
NCBI Full Name:Parvalbumin alpha
NCBI Synonym Full Names:parvalbumin
NCBI Official Symbol:PVALB��
NCBI Official Synonym Symbols:D22S749��
NCBI Protein Information:parvalbumin alpha
UniProt Protein Name:Parvalbumin alpha
Protein Family:Parvalbumin
UniProt Gene Name:PVALB��
UniProt Entry Name:PRVA_HUMAN

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