Human PTPN4 Recombinant Protein (RPPB2641)
- SKU:
- RPPB2641
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P29074
- Research Area:
- Enzymes
Description
| Product Name: | Human PTPN4 Recombinant Protein |
| Product Code: | RPPB2641 |
| Size: | 20µg |
| Species: | Human |
| Target: | PTPN4 |
| Synonyms: | Protein Tyrosine Phosphatase, Non-Receptor Type 4(Megakaryocyte), Protein-Tyrosine Phosphatase MEG1, PTPase-MEG1, EC 3.1.3.48,MEG, Tyrosine-Protein Phosphatase Non-Receptor Type 4, MegakaryocyteProtein-Tyrosine Phosphatase, Protein Tyrosine Phosphatase MEG1, MegakaryocytePhosphatase, PTPMEG1, PTPMEG, Tyrosine-protein phosphatase non-receptor type 4,Protein-tyrosine phosphatase MEG1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PTPN4 protein solution (1mg/ml) containing 20mM Trisbuffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MVLTQFDQLY RKKPGMTMSC AKLPQNISKN RYRDISPYDA TRVILKGNED YINANYINMEIPSSSIINQY IACQGPLPHT CTDFWQMTWE QGSSMVVMLT TQVERGRVKC HQYWPEPTGS SSYGCYQVTCHSEEGNTAYI FRKMTLFNQE KNESRPLTQI QYIAWPDHGV PDDSSDFLDF VCHVRNKRAG KEEPVVVHCSAGIGRTGVLI TMETAMCLIE CNQPVYPLDI VRTMRDQRAM MIQTPSQYRF VCEAILKVYE |
Protein Tyrosine Phosphatase Non Receptor Type-4, also known as PTPN4belongs to the protein tyrosine phosphatase, PTP family. PTPs are identified assignaling molecules which regulate a variety of cellular processes as well ascell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN4is broadly expressed non-receptor protein tyrosine phosphatase. In addition, PTPN4interacts with glutamate receptor delta 2 & epsilon, and affects glutamatereceptors signaling and/or in regulation of their activities through tyrosine dephosphorylation.
PTPN4 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 280 amino acids (655-913 a.a) and having amolecular mass of 32kDa.PTPN4 is fused to a 21 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PTPN4: May act at junctions between the membrane and the cytoskeleton. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. |
| UniProt Protein Details: | Protein type:Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 2q14.2 Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm Molecular Function:protein binding; cytoskeletal protein binding; non-membrane spanning protein tyrosine phosphatase activity Biological Process: protein amino acid dephosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29074 |
| NCBI GenInfo Identifier: | 131531 |
| NCBI Gene ID: | 5775 |
| NCBI Accession: | P29074.1 |
| UniProt Secondary Accession: | P29074,Q9UDA7, B2RBV8, |
| UniProt Related Accession: | P29074 |
| Molecular Weight: | 926 |
| NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 4 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) |
| NCBI Official Symbol: | PTPN4�� |
| NCBI Official Synonym Symbols: | MEG; PTPMEG; PTPMEG1�� |
| NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 4; PTPase-MEG1; megakaryocyte phosphatase; protein tyrosine phosphatase MEG1; protein-tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase |
| UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 4 |
| UniProt Synonym Protein Names: | Protein-tyrosine phosphatase MEG1; MEG; PTPase-MEG1 |
| Protein Family: | Tyrosine-protein phosphatase non-receptor |
| UniProt Gene Name: | PTPN4�� |
| UniProt Entry Name: | PTN4_HUMAN |
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