Human PSTPIP1 Recombinant Protein (RPPB4330)
- SKU:
- RPPB4330
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43586
Description
| Product Name: | Human PSTPIP1 Recombinant Protein |
| Product Code: | RPPB4330 |
| Size: | 20µg |
| Species: | Human |
| Target: | PSTPIP1 |
| Synonyms: | Proline-serine-threonine phosphatase interacting protein 1, CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP, PSTPIP1, Proline-serine-threonine phosphatase-interacting protein 1, PEST phosphatase-interacting protein 1, CD2-binding protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PSTPIP1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMMPQLQF KDAFWCRDFT AHTGYEVLLQ RLLDGRKMCK DMEELLRQRA QAEERYGKEL VQIARKAGGQ TEINSLRASF DSLKQQMENV GSSHIQLALT LREELRSLEE FRERQKEQRK KYEAVMDRVQ KSKLSLYKKA MESKKTYEQK CRDADDAEQA FERISANGHQ KQVEKSQNKA RQCKDSATEA ERVYRQSIAQ LEKVRAEWEQ EHRTTCEAFQ LQEFDRLTIL RNALWVHSNQ LSMQCVKDDE LYEEVRLTLE GCSIDADIDS FIQAKSTGTE PPAPVPYQNY YDREVTPLTS SPGIQPSCGM IKRFSGLLHG SPKTTSLAAS AASTETLTPT PERNEGVYTA IAVQEIQGNP ASPAQEYRAL YDYTAQNPDE LDLSAGDILE VILEGEDGWW TVERNGQRGF VPGSYLEKL |
Proline-Serine-Threonine Phosphatase Interacting Protein 1 (PSTPIP1) which is a scaffold protein and a regulator of the actin cytoskeleton binds ABL1, PTPN18, WAS, CD2AP, and PTPN12. PSTPIP1 also binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. Mutations in PSTPIP1 are a cause of PAPA syndrome.
PSTPIP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 439 amino acids (1-416) and having a molecular mass of 50 kDa.PSTPIP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PSTPIP1: an SH3-domain containing protein that may play a role in vesicle formation and transport. Interacts with PTP-PEST to inhibit WASp-driven actin polymerization and synapse formation. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 15q24.3 Cellular Component: membrane; lamellipodium; perinuclear region of cytoplasm; contractile ring; stress fiber; uropod; cytosol; cleavage furrow Molecular Function:protein binding; actin binding; protein phosphatase binding Biological Process: innate immune response; endocytosis; inflammatory response; signal transduction; cell adhesion Disease: Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne |
| NCBI Summary: | The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43586 |
| NCBI GenInfo Identifier: | 74739557 |
| NCBI Gene ID: | 9051 |
| NCBI Accession: | O43586.1 |
| UniProt Secondary Accession: | O43586,O43585, O95657, B5BU74, B5BUK4, |
| UniProt Related Accession: | O43586 |
| Molecular Weight: | 416 |
| NCBI Full Name: | Proline-serine-threonine phosphatase-interacting protein 1 |
| NCBI Synonym Full Names: | proline-serine-threonine phosphatase interacting protein 1 |
| NCBI Official Symbol: | PSTPIP1�� |
| NCBI Official Synonym Symbols: | H-PIP; PAPAS; CD2BP1; PSTPIP; CD2BP1L; CD2BP1S�� |
| NCBI Protein Information: | proline-serine-threonine phosphatase-interacting protein 1; CD2-binding protein 1; CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; PEST phosphatase-interacting protein 1 |
| UniProt Protein Name: | Proline-serine-threonine phosphatase-interacting protein 1 |
| UniProt Synonym Protein Names: | CD2-binding protein 1; H-PIP |
| Protein Family: | Proline-serine-threonine phosphatase-interacting protein |
| UniProt Gene Name: | PSTPIP1�� |
| UniProt Entry Name: | PPIP1_HUMAN |
