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Human PRTN3 Recombinant Protein (RPPB2296)

SKU:
RPPB2296
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P24158
Research Area:
Enzymes
€309
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Description

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Product Name:Human PRTN3 Recombinant Protein
Product Code:RPPB2296
Size:10µg
Species:Human
Target:PRTN3
Synonyms:AGP7, P29, PR-3, ACPA, C-ANCA, MBT, MBN, Leukocyte proteinase 3, Neutrophil proteinase 4, Wegener granulomatosis autoantigen, Azurophil granule protein 7, myeloblastin, Serine proteinase neutrophil.
Source:Native
Formulation:PRTN3�is supplied in 20mM Sodium Phosphate pH-6.2, 300mM NaCl, and 0.02% Lubrol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% in the sum of different glycosylation isoforms according to following section�as determined by SDS-PAGE and capillary electrophoresis.

PRTN3 is a polymorphonuclear leukocyte serine protease which degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema once managed by tracheal insufflation to hamsters.

PRTN3 is a natural antigen having a molecular mass of 25kDa. PRTN3 is isolated from human peripheral blood leukocytes.

UniProt Protein Function:PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily.
UniProt Protein Details:

Protein type:EC 3.4.21.76; Cell cycle regulation; Protease

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytosol; extracellular matrix; extracellular space; plasma membrane

Molecular Function:enzyme binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: blood coagulation; negative regulation of phagocytosis; positive regulation of cell proliferation

UniProt Code:P24158
NCBI GenInfo Identifier:6174926
NCBI Gene ID:5657
NCBI Accession:P24158.3
UniProt Secondary Accession:P24158,P15637, P18078, Q4VB08, Q4VB09, Q6LBM7, Q6LBN2 Q9UD25, Q9UQD8,
UniProt Related Accession:P24158
Molecular Weight:27,807 Da
NCBI Full Name:Myeloblastin
NCBI Synonym Full Names:proteinase 3
NCBI Official Symbol:PRTN3��
NCBI Official Synonym Symbols:MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA��
NCBI Protein Information:myeloblastin
UniProt Protein Name:Myeloblastin
UniProt Synonym Protein Names:AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
Protein Family:Myeloblastin
UniProt Gene Name:PRTN3��
UniProt Entry Name:PRTN3_HUMAN

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