Human Pro-Collagen I alpha Polyclonal Antibody (CAB24863)
- SKU:
- CAB24863
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IHC
- IF
Description
Product Name: | Human Pro-Collagen I alpha Polyclonal Antibody |
SKU: | CAB24863 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-161 of human Collagen I/COL1A1 (NP_000079.2). |
Sequence: | GQVE GQDE DIPP ITCV QNGL RYHD RDVW KPEP CRIC VCDN GKVL CDDV ICDE TKNC PGAE VPEG ECCP VCPD GSES PTDQ ETTG VEGP KGDT GPRG PRGP AGPP GRDG IPGQ PGLP GPPG PPGP PGPP GLGG NFAP |
Tested Applications: | WB IHC-P IF/ICC |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | COL1A1; EDSC; OI1; OI2; OI3; OI4; collagen alpha-1(I) chain; Human Pro-Collagen I alpha |
Positive Sample: | U-138 MG |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 138kDa |
Observed MW: | 220kDa |
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1277 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |