Human Pro-Collagen I alpha Polyclonal Antibody (CAB24863)
The Human Pro-collagen I Alpha Polyclonal Antibody is a valuable tool for researchers studying collagen production and tissue development. This antibody, generated in rabbits, is specifically designed to target the pro-collagen I alpha chain, a key component in collagen synthesis. With its high reactivity towards human samples, this antibody is ideal for use in Western blotting applications to detect and analyze pro-collagen I alpha in various cell types. Its specificity allows for accurate and reliable results, making it a trusted resource for studies in regenerative medicine, wound healing, and extracellular matrix remodeling.Pro-collagen I alpha is essential for maintaining the structural integrity of tissues and organs, making it a crucial focus in research on fibrosis, scarring, and connective tissue disorders.
By understanding the regulation and expression of this protein, researchers can gain insights into potential therapeutic targets for conditions related to collagen dysfunction.Overall, the Human Pro-collagen I Alpha Polyclonal Antibody provides researchers with a reliable tool to explore the biology of collagen production and its role in maintaining tissue function and structure. Its versatility and specificity make it an invaluable asset for studies in the fields of biology, medicine, and tissue engineering.
Product Name:
Human Pro-Collagen I alpha Polyclonal Antibody
SKU:
CAB24863
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-161 of human Collagen I/COL1A1 (NP_000079.2).
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
1277
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from U-138 MG cells using Human Pro-Collagen I alpha Rabbit pAb(CAB24863) at 1:2000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Enhanced Kit (AbGn00021).Exposuretime:30s.
